Molecular structure of Zolmitriptan, CAS Number: 139264-17-8
Zolmitriptan (CAS 139264-17-8)
Alternate Names:
(4S)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl-2-oxazolidinone; BW-311C90; Zomig
Application:
Zolmitriptan is a serotonin 5HTID-receptor agonist
CAS Number:
139264-17-8
Purity:
≥99%
Molecular Weight:
287.36
Molecular Formula:
C16H21N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Zolmitriptan is a Serotonin 5HTID-receptor agonist.
Zolmitriptan (CAS 139264-17-8) References
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- Review of zolmitriptan and its clinical applications in migraine. | Dowson, AJ. and Charlesworth, B. 2002. Expert Opin Pharmacother. 3: 993-1005. PMID: 12083998
- Zolmitriptan for treatment of migrainous vertigo: a pilot randomized placebo-controlled trial. | Neuhauser, H., et al. 2003. Neurology. 60: 882-3. PMID: 12629256
- Migraine prevalence and treatment patterns: the global Migraine and Zolmitriptan Evaluation survey. | MacGregor, EA., et al. 2003. Headache. 43: 19-26. PMID: 12864754
- Intranasal mucoadhesive microemulsions of zolmitriptan: preliminary studies on brain-targeting. | Vyas, TK., et al. 2005. J Drug Target. 13: 317-24. PMID: 16199375
- Effectiveness of intranasal zolmitriptan in acute cluster headache: a randomized, placebo-controlled, double-blind crossover study. | Cittadini, E., et al. 2006. Arch Neurol. 63: 1537-42. PMID: 16966497
- Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial. | Ho, TW., et al. 2008. Lancet. 372: 2115-23. PMID: 19036425
- Preparation of zolmitriptan-chitosan microparticles by spray drying for nasal delivery. | Alhalaweh, A., et al. 2009. Eur J Pharm Sci. 38: 206-14. PMID: 19616094
- Poloxamer 407-based intranasal thermoreversible gel of zolmitriptan-loaded nanoethosomes: formulation, optimization, evaluation and permeation studies. | Shelke, S., et al. 2016. J Liposome Res. 26: 313-23. PMID: 26758957
- Trans-nasal zolmitriptan novasomes: in-vitro preparation, optimization and in-vivo evaluation of brain targeting efficiency. | Abd-Elal, RM., et al. 2016. Drug Deliv. 23: 3374-3386. PMID: 27128792
- Computer-aided design and synthesis of 5-substituted tryptamines and their pharmacology at the 5-HT1D receptor: discovery of compounds with potential anti-migraine properties. | Glen, RC., et al. 1995. J Med Chem. 38: 3566-80. PMID: 7658443
- The tolerability and pharmacokinetics of the novel antimigraine compound 311C90 in healthy male volunteers. | Seaber, E., et al. 1996. Br J Clin Pharmacol. 41: 141-7. PMID: 8838441
- Inhibition of trigeminal neurons by intravenous administration of the serotonin (5HT)1B/D receptor agonist zolmitriptan (311C90): are brain stem sites therapeutic target in migraine? | Goadsby, PJ. and Hoskin, KL. 1996. Pain. 67: 355-9. PMID: 8951929
- Optimizing the dose of zolmitriptan (Zomig, 311C90) for the acute treatment of migraine. A multicenter, double-blind, placebo-controlled, dose range-finding study. The 017 Clinical Trial Study Group. | Rapoport, AM., et al. 1997. Neurology. 49: 1210-8. PMID: 9371896
- Pre-clinical pharmacology of zolmitriptan (Zomig; formerly 311C90), a centrally and peripherally acting 5HT1B/1D agonist for migraine. | Martin, GR. 1997. Cephalalgia. 17 Suppl 18: 4-14. PMID: 9399012
Activator of:
SR-1B, and SR-1D.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Zolmitriptan, 10 mg | sc-220415 | 10 mg | $186.00 |