Molecular structure of Zofenoprilat-d5, CAS Number: 1217716-12-5
Zofenoprilat-d5 (CAS 1217716-12-5)
Alternate Names:
(4S)-1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-4-(phenyl-d5-thio)-L-proline
Application:
Zofenoprilat-d5 is an active metabolite of Zofenopril
CAS Number:
1217716-12-5
Molecular Weight:
330.48
Molecular Formula:
C15H14D5NO3S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Zofenoprilat-d5 is an active metabolite of Zofenopril. Zenopril is an antioxidant that acts as an angiotensin-converting enzyme inhibitor. Studies indicate that Zenopril increases the calcium cycling of sarcoplasmic reticulum and enhances active calcium uptake into the sarcoplasmic reticulum. The compounds Zenopril and Captopril are suggested to be the only ACE inhibitors that structurally have sulphydryl groups (SH). Zenopril has been reported to to convert into Zofeniprilate, the active free sulfhydryl compound, after metabolic hydrolysis. Additional Zofenopril metabolites include: Zofenopril Acyl--D-glucuronide (sc-220407)
Zofenoprilat-d5 (CAS 1217716-12-5) References
- Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry. | Dal Bo, L., et al. 2000. J Chromatogr B Biomed Sci Appl. 749: 287-94. PMID: 11145066
- A review of the angiotensin-converting enzyme inhibitor, zofenopril, in the treatment of cardiovascular diseases. | Borghi, C., et al. 2004. Expert Opin Pharmacother. 5: 1965-77. PMID: 15330734
- Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model. | Kalender, AM., et al. 2009. J Brachial Plex Peripher Nerve Inj. 4: 6. PMID: 19508704
- Effects of zofenopril on cardiac sarcoplasmic reticulum calcium handling. | Frascarelli, S., et al. 2009. J Cardiovasc Pharmacol. 54: 456-63. PMID: 19738489
- Differences between zofenopril and ramipril, two ACE inhibitors, on cough induced by citric acid in guinea pigs: role of bradykinin and PGE2. | Cialdai, C., et al. 2010. Naunyn Schmiedebergs Arch Pharmacol. 382: 455-61. PMID: 20848272
Inhibitor of:
ACE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Zofenoprilat-d5, 1 mg | sc-220412 | 1 mg | $430.00 |