ZNF76 Antibody (A-11): sc-374645
- ZNF76 Antibody (A-11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 364-463 mapping within an internal region of ZNF76 of human origin
- recommended for detection of ZNF76 of human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-374645 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ZNF76 Antibody (A-11). This work is in progress.
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SEE ALSO...
ZNF76 Antibody (A-11) is a mouse monoclonal IgG1 antibody that detects ZNF76 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZNF76, also known as ZNF523 or Zfp523, is a transcriptional repressor predominantly expressed in the testis, where ZNF76 plays a crucial role in regulating gene expression. ZNF76 is essential for proper transcriptional control of genes encoding small nuclear RNA and selenocysteine tRNA, as ZNF76 is the human homolog of the Xenopus Staf protein, which activates these genes. ZNF76 is localized in the nucleus, where ZNF76 exerts inhibitory function on p53-mediated transactivation, specifically targeting the TFIID complex through interactions with both N and C termini. Post-translational modifications, particularly lysine acetylation and sumoylation, significantly influence ZNF76′s transcriptional repression activity. Acetylation, mediated by p300, leads to a loss of sumoylation and weakened interaction with TFIID, while deacetylation by HDAC1 can restore repressive function. Additionally, splice variants of ZNF76 introduce further complexity to regulatory mechanisms, as these isoforms exhibit differing abilities to interact with TFIID, highlighting ZNF76′s importance in maintaining cellular homeostasis and potential implications in various biological processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZNF76 Antibody (A-11) | sc-374645 | 200 µg/ml | $322.00 | |||
ZNF76 Antibody (A-11) X | sc-374645 X | 200 µg/0.1 ml | $322.00 |