ZNF384 Antibody (3545C5a): sc-517543

ZNF384 Antibody (3545C5a) is a mouse monoclonal IgG1 antibody that detects the ZNF384 protein of human origin by western blotting (WB). Anti-ZNF384 antibody (3545C5a) is available as a non-conjugated format. ZNF384, also known as zinc finger protein 384, CAGH1, CIZ, NMP4, or TNRC1, is a crucial 577 amino acid nuclear protein that plays a significant role in gene regulation. ZNF384 contains eight C2H2-type zinc fingers and is classified within the Krüppel C2H2-type zinc-finger protein family, which is essential for function as a transcription factor. ZNF384 binds to specific DNA sequences, particularly the consensus sequence [GC]AAAAA, allowing regulation of various target genes, including MMP-1, MMP-3, MMP-7, and COL1A1, which are involved in critical cellular processes such as tissue remodeling and response to injury. The gene encoding ZNF384 is located on human chromosome 12p13.31 and spans over 23,000 bases, highlighting complexity and importance in cellular function. ZNF384 interacts with p130 Cas, a protein that plays a role in signaling pathways related to cell adhesion and migration, further emphasizing significance in cellular dynamics and potential implications in cancer and other diseases.

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ZNF384 Antibody (3545C5a) References:

1. CIZ, a zinc finger protein that interacts with p130(cas) and activates the expression of matrix metalloproteinases.  |  Nakamoto, T., et al. 2000. Mol Cell Biol. 20: 1649-58. PMID: 10669742
2. Assignment of Nmp4 to mouse chromosome 6 band F1 flanked by D6Mit134 and D6Mit255 using radiation hybrid mapping and fluorescence in situ hybridization.  |  Alvarez, MB., et al. 2001. Cytogenet Cell Genet. 94: 244-5. PMID: 11856889
3. Negative regulation of bone morphogenetic protein/Smad signaling by Cas-interacting zinc finger protein in osteoblasts.  |  Shen, ZJ., et al. 2002. J Biol Chem. 277: 29840-6. PMID: 12023967
4. The nucleocytoplasmic shuttling protein CIZ reduces adult bone mass by inhibiting bone morphogenetic protein-induced bone formation.  |  Morinobu, M., et al. 2005. J Exp Med. 201: 961-70. PMID: 15781586
5. E2A-ZNF384 and NOL1-E2A fusion created by a cryptic t(12;19)(p13.3; p13.3) in acute leukemia.  |  Zhong, CH., et al. 2008. Leukemia. 22: 723-9. PMID: 18185522
6. TAF15 and the leukemia-associated fusion protein TAF15-CIZ/NMP4 are cleaved by caspases-3 and -7.  |  Alves, J., et al. 2009. Biochem Biophys Res Commun. 384: 495-500. PMID: 19426707
7. Identification of the TAF15-ZNF384 fusion gene in two new cases of acute lymphoblastic leukemia with a t(12;17)(p13;q12).  |  Nyquist, KB., et al. 2011. Cancer Genet. 204: 147-52. PMID: 21504714

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZNF384 Antibody (3545C5a) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ZNF384 Antibody (3545C5a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZNF384 Antibody (3545C5a) Specifications

Alternate Product Name: ZNF384

Product Clone Name: 3545C5a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: ZNF384

Epitope Species: human

Product Reactivity/Detection: ZNF384

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ZNF384 Antibody (3545C5a): N/A