ZNF354A Antibody (149C1a): sc-81140

ZNF354A Antibody (149C1a) is a mouse monoclonal IgG1 antibody that detects ZNF354A protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-ZNF354A antibody (149C1a) is available as a non-conjugated format. ZNF354A protein, also known as EZNF, KID-1, or TCF17, is a member of the Krüppel C2H2-type zinc-finger family, characterized by the presence of KRAB domains that function as transcriptional regulators. ZNF354A is predominantly expressed in the adult kidney, where ZNF354A serves as a transcriptional repressor crucial for late renal development and is notably suppressed following renal ischemia. The structure of ZNF354A is particularly important, as its N-terminus contains the KRAB domain, which is essential for repressor activity, while the C-terminus is composed of multiple Cys2His2 zinc fingers that facilitate DNA binding. Located in the nucleolus, ZNF354A plays a significant role in the development of the proximal tubule by regulating the expression of genes that are either dispensable or inhibitory. A reduction in ZNF354A expression can hinder proper cell differentiation, potentially leading to implications in renal carcinoma, highlighting the importance of ZNF354A in maintaining renal health and function.

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ZNF354A Antibody (149C1a) References:

1. Expression of the transcriptional repressor protein Kid-1 leads to the disintegration of the nucleolus.  |  Huang, Z., et al. 1999. J Biol Chem. 274: 7640-8. PMID: 10075651
2. Characterization of the mouse Kid1 gene and identification of a highly related gene, Kid2.  |  Tekki-Kessaris, N., et al. 1999. Gene. 240: 13-22. PMID: 10564808
3. The tcf17 gene at chromosome 5q is not involved in the development of conventional renal cell carcinoma.  |  Bugert, P., et al. 2000. Int J Cancer. 86: 806-10. PMID: 10842194
4. U7 snRNP-specific Lsm11 protein: dual binding contacts with the 100 kDa zinc finger processing factor (ZFP100) and a ZFP100-independent function in histone RNA 3' end processing.  |  Azzouz, TN., et al. 2005. Nucleic Acids Res. 33: 2106-17. PMID: 15824063
5. Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury.  |  Witzgall, R., et al. 1993. Mol Cell Biol. 13: 1933-42. PMID: 8382778
6. Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1.  |  Omori, Y., et al. 1997. Cytogenet Cell Genet. 78: 285-8. PMID: 9465904
7. Kid-1 expression is high in differentiated renal proximal tubule cells and suppressed in cyst epithelia.  |  Witzgall, R., et al. 1998. Am J Physiol. 275: F928-37. PMID: 9843910
8. Molecular cloning of a zinc finger gene eZNF from a human inner ear cDNA library, and in situ expression pattern of its mouse homologue in mouse inner ear.  |  Jacob, AN., et al. 1998. Somat Cell Mol Genet. 24: 121-9. PMID: 9919311

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZNF354A Antibody (149C1a) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ZNF354A Antibody (149C1a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZNF354A Antibody (149C1a) Specifications

Alternate Product Name: ZNF354A

Product Clone Name: 149C1a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: ZNF354A

Epitope Species: human

Product Reactivity/Detection: ZNF354A

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ZNF354A Antibody (149C1a): N/A