ZNF224 Antibody (2C12): sc-293394

ZNF224 Antibody (2C12) is a mouse monoclonal IgG2a kappa light chain antibody that detects the ZNF224 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). ZNF224 (2C12) antibody is available as a non-conjugated anti-ZNF224 monoclonal isotype antibody. Zinc finger protein 224 (ZNF224), also known as BMZF2, KOX22, ZNF233, ZNF255, or ZNF27, is a 707 amino acid member of the Krüppel C2H2-type zinc-finger protein family, primarily localized in the nucleus. ZNF224 plays a crucial role in transcriptional regulation due to its structure, which includes eighteen C2H2-type zinc fingers and one KRAB domain. The presence of these zinc fingers allows ZNF224 to bind to specific DNA sequences, thereby influencing gene expression. ZNF224′s interaction with the KRAB domain facilitates the recruitment of histone-modifying proteins, which are essential for chromatin remodeling and gene silencing. ZNF224 is predominantly expressed in fetal tissues and has been shown to interact with Wilms tumor 1 (WT1), a key regulator in kidney development and tumorigenesis, thereby modulating its transactivation capabilities. This functional interplay highlights ZNF224′s importance in developmental processes and potential implications in cancer biology.

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ZNF224 Antibody (2C12) References:

1. Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB.  |  Han, ZG., et al. 1999. J Biol Chem. 274: 35741-8. PMID: 10585455
2. Physical mapping and evolution of the centromeric class I gene-containing region of the rat MHC.  |  Walter, L. and Günther, E. 2000. Immunogenetics. 51: 829-37. PMID: 10970097
3. Inhibition of Wilms tumor 1 transactivation by bone marrow zinc finger 2, a novel transcriptional repressor.  |  Lee, TH., et al. 2002. J Biol Chem. 277: 44826-37. PMID: 12239212
4. A novel zinc finger transcriptional repressor, ZNF224, interacts with the negative regulatory element (AldA-NRE) and inhibits gene expression.  |  Medugno, L., et al. 2003. FEBS Lett. 534: 93-100. PMID: 12527367
5. Context-dependent DNA recognition code for C2H2 zinc-finger transcription factors.  |  Liu, J. and Stormo, GD. 2008. Bioinformatics. 24: 1850-7. PMID: 18586699
6. Multiple genes encoding zinc finger domains are expressed in human T cells.  |  Thiesen, HJ. 1990. New Biol. 2: 363-74. PMID: 2288909
7. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs.  |  Rosenfeld, R. and Margalit, H. 1993. J Biomol Struct Dyn. 11: 557-70. PMID: 8129873
8. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19.  |  Rousseau-Merck, MF., et al. 1993. Hum Genet. 92: 583-7. PMID: 8262519

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZNF224 Antibody (2C12) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ZNF224 Antibody (2C12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZNF224 Antibody (2C12) Specifications

Alternate Product Name: ZNF224

Product Clone Name: 2C12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 95-190

Epitope Target: ZNF224

Epitope Species: human

Product Reactivity/Detection: ZNF224

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ZNF224 Antibody (2C12): N/A