ZNF202 Antibody (GG-7): sc-101074

ZNF202 Antibody (GG-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects ZNF202 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). ZNF202 (GG-7) antibody is available as the non-conjugated form. ZNF202 protein, also known as zinc finger protein 202 or ZKSCAN10, is a 648 amino acid protein characterized by eight C2H2-type zinc fingers, one KRAB domain, and one SCAN box domain, which are crucial for function as a transcriptional repressor. ZNF202 is primarily localized in the nucleus and highly expressed in the testis, where ZNF202 plays a significant role in regulating genes involved in lipid metabolism. Through modulating expression of various proteins, including those related to lipoprotein particles, lipid transporters, and enzymes involved in lipid processing, ZNF202 is essential for maintaining lipid homeostasis and energy metabolism. Defects in the gene encoding ZNF202 have been linked to high cholesterol levels and may contribute to the development of lung, ovarian, and breast cancers. Two isoforms of ZNF202, designated alpha and beta, arise from alternative splicing, further highlighting the complexity and regulatory potential of this protein.

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ZNF202 Antibody (GG-7) References:

1. A broad role for the zinc finger protein ZNF202 in human lipid metabolism.  |  Wagner, S., et al. 2000. J Biol Chem. 275: 15685-90. PMID: 10748193
2. The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux.  |  Porsch-Ozcurumez, M., et al. 2001. J Biol Chem. 276: 12427-33. PMID: 11279031
3. Cross talk of two Krupple transcription factors regulates expression of the ovine FSH receptor gene.  |  Xing, W. and Sairam, MR. 2002. Biochem Biophys Res Commun. 295: 1096-101. PMID: 12135607
4. ZNF202 is inversely regulated with its target genes ABCA1 and apoE during macrophage differentiation and foam cell formation.  |  Langmann, T., et al. 2003. J Lipid Res. 44: 968-77. PMID: 12611910
5. Zinc finger protein ZNF202 structure and function in transcriptional control of HDL metabolism.  |  Schmitz, G., et al. 2004. Curr Opin Lipidol. 15: 199-208. PMID: 15017363
6. Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study.  |  Stene, MC., et al. 2006. Atherosclerosis. 188: 43-50. PMID: 16289551
7. High throughput SNP and expression analyses of candidate genes for non-syndromic oral clefts.  |  Park, JW., et al. 2006. J Med Genet. 43: 598-608. PMID: 16415175
8. Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population.  |  Stene, MC., et al. 2006. J Lipid Res. 47: 944-52. PMID: 16467280
9. Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins.  |  Monaco, C., et al. 1998. Genomics. 52: 358-62. PMID: 9790754

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZNF202 Antibody (GG-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ZNF202 Antibody (GG-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZNF202 Antibody (GG-7) Specifications

Alternate Product Name: ZNF202

Product Clone Name: GG-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 301-401

Epitope Target: ZNF202

Epitope Species: human

Product Reactivity/Detection: ZNF202

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ZNF202 Antibody (GG-7): N/A