ZNF136 Antibody (ZNF1H5D11): sc-81133
- ZNF136 Antibody (ZNF1H5D11) is a mouse monoclonal IgG2b ZNF136 antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to an internal region of ZNF136 of human origin
- recommended for detection of ZNF136 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ZNF136 Antibody (ZNF1H5D11). This work is in progress.
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ZNF136 Antibody (ZNF1H5D11) is a mouse monoclonal IgG2b antibody that detects ZNF136 protein of human origin by western blotting (WB) and immunoprecipitation (IP). ZNF136 (ZNF1H5D11) monoclonal antibody is available as a non-conjugated format. ZNF136 plays a crucial role as a transcriptional regulator within the Krüppel C2H2-type zinc-finger protein family, which is essential for various cellular processes, including gene expression regulation. ZNF136 is predominantly located in the nucleus, where ZNF136 interacts with DNA to modulate transcriptional activity. ZNF136 contains 14 C2H2-type zinc fingers and one KRAB A-domain, which are vital for DNA sequence binding functions. While ZNF136 acts as a weak repressor independently, ZNF136′s repressive capabilities are significantly enhanced when fused with other proteins containing KRAB B-domains, such as ZNF10. This interaction is important for recruiting histone-modifying proteins, which further influence chromatin structure and gene expression. ZNF136′s ability to regulate transcription highlights its significance in cellular function and potential implications in various biological processes and diseases.
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ZNF136 Antibody (ZNF1H5D11) References:
- KRAB-containing zinc-finger repressor proteins. | Urrutia, R. 2003. Genome Biol. 4: 231. PMID: 14519192
- A novel Krüppel related factor consisting of only a KRAB domain is expressed in the murine trigeminal ganglion. | Nikulina, K., et al. 2006. Biochem Biophys Res Commun. 348: 839-49. PMID: 16904636
- Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. | Tommerup, N. and Vissing, H. 1995. Genomics. 27: 259-64. PMID: 7557990
- Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. | Vissing, H., et al. 1995. FEBS Lett. 369: 153-7. PMID: 7649249
- Repression of transcriptional activity at a distance by the evolutionarily conserved KRAB domain present in a subfamily of zinc finger proteins. | Pengue, G., et al. 1994. Nucleic Acids Res. 22: 2908-14. PMID: 8065901
- Krüppel-associated boxes are potent transcriptional repression domains. | Margolin, JF., et al. 1994. Proc Natl Acad Sci U S A. 91: 4509-13. PMID: 8183939
- The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. | Witzgall, R., et al. 1994. Proc Natl Acad Sci U S A. 91: 4514-8. PMID: 8183940
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZNF136 Antibody (ZNF1H5D11) | sc-81133 | 100 µg/ml | $339.00 |