Date published: 2025-9-5

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ZnAF-2F (CAS 443302-09-8)

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Alternate Names:
6-{2-[Bis(2-pyridylmethyl)amino]ethylamino}-2′,7′-difluorofluorescein
Application:
ZnAF-2F is suitable for the fluorimetric detection of Zn 2+.
CAS Number:
443302-09-8
Molecular Weight:
608.59
Molecular Formula:
C34H26F2N4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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suitable for the fluorimetric detection of Zn2+, (1)


ZnAF-2F (CAS 443302-09-8) References

  1. A fluorescent PEBBLE nanosensor for intracellular free zinc.  |  Sumner, JP., et al. 2002. Analyst. 127: 11-6. PMID: 11827375
  2. Improvement and biological applications of fluorescent probes for zinc, ZnAFs.  |  Hirano, T., et al. 2002. J Am Chem Soc. 124: 6555-62. PMID: 12047174
  3. Evidence for pH dependent Zn2+influx in K562 erythroleukemia cells: studies using ZnAF-2F fluorescence and 65Zn2+ uptake.  |  Colvin, RA., et al. 2005. Arch Biochem Biophys. 442: 222-8. PMID: 16183033
  4. Insights into Zn2+ homeostasis in neurons from experimental and modeling studies.  |  Colvin, RA., et al. 2008. Am J Physiol Cell Physiol. 294: C726-42. PMID: 18184873
  5. Cytosolic zinc buffering and muffling: their role in intracellular zinc homeostasis.  |  Colvin, RA., et al. 2010. Metallomics. 2: 306-17. PMID: 21069178
  6. Zinc is externalized rather than released during synaptic transmission.  |  Nydegger, I., et al. 2010. ACS Chem Neurosci. 1: 728-736. PMID: 21221416
  7. Ternary complex formation and competition quench fluorescence of ZnAF family zinc sensors.  |  Staszewska, A., et al. 2013. Metallomics. 5: 1483-90. PMID: 23939683
  8. Determination of the relative contribution of the non-dissolved fraction of ZnO NP on membrane permeability and cytotoxicity.  |  Ziglari, T., et al. 2020. Inhal Toxicol. 32: 86-95. PMID: 32216500
  9. From methodological limitations to the function of metallothioneins - a guide to approaches for determining weak, moderate, and tight affinity zinc sites.  |  Pomorski, A., et al. 2023. Metallomics. 15: PMID: 37113075
  10. Differentiated Zn(II) binding affinities in animal, plant, and bacterial metallothioneins define their zinc buffering capacity at physiological pZn.  |  Mosna, K., et al. 2023. Metallomics. 15: PMID: 37804185

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

ZnAF-2F, 1 mg

sc-216075
1 mg
$172.00

ZnAF-2F, 5 mg

sc-216075A
5 mg
$660.00

ZnAF-2F, 25 mg

sc-216075B
25 mg
$2250.00