Molecular structure of ZnAF-2 tetrahydrochloride, CAS Number: 321859-11-4
ZnAF-2 tetrahydrochloride
Alternate Names:
6-{2-[Bis(2-pyridylmethyl)amino]ethylamino}fluorescein Tetrahydrochloride
Application:
ZnAF-2 tetrahydrochloride is a high-affinity Zn2+-specific fluorescent probe
Molecular Weight:
718.45
Molecular Formula:
C34H28N4O5•4HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
This is a membrane-impermeable ethylenediaminofluoresceinyl compound that acts as a high-affinity Zn2+-specific fluorescent probe (Kd = 2.7 nM). It has a low basal fluorescence and the fluorescence intensity increases ~51-fold upon stoichiometric (1:1) binding to Zn2+. it exhibits little affinity towards Ca2+, Na+, Mg2+, or K+. This has been used successfully in monitoring spatio-temporal dynamics of extracellular Zn2+ release in rat hippocampal samples. A cell-permeable, diacetylated form of ZnAF-2 is also available for intracellular use.
ZnAF-2 tetrahydrochloride References
- Improvement and biological applications of fluorescent probes for zinc, ZnAFs. | Hirano, T., et al. 2002. J Am Chem Soc. 124: 6555-62. PMID: 12047174
- Mossy fiber Zn2+ spillover modulates heterosynaptic N-methyl-D-aspartate receptor activity in hippocampal CA3 circuits. | Ueno, S., et al. 2002. J Cell Biol. 158: 215-20. PMID: 12119362
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZnAF-2 tetrahydrochloride, 1 mg | sc-222429 | 1 mg | $487.00 |