Molecular structure of ZnAF-2 DA, CAS Number: 357339-96-9
ZnAF-2 DA (CAS 357339-96-9)
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Alternate Names:
6-[N-[N′,N′-bis(2-Pyridinylmethyl)-2-aminoethyl]amino-3′,6′-bis(acetyloxy)-spiro[isobenzofuran-1(3H),9′-[9H]xanthen]-3-one
Application:
ZnAF-2 DA is a fluorescent reagent used to detect zinc
CAS Number:
357339-96-9
Molecular Weight:
656.68
Molecular Formula:
C38H32N4O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ZnAF-2 DA is a cell permeable derivative of ZnAF-2. A fluorescent reagent employed in the detection of low concentrations of zinc ion due to its strong affinity for the zinc ion. Zinc can be found in every cell in the human body. The zinc ion can be specifically detected.
ZnAF-2 DA (CAS 357339-96-9) References
- Improvement and biological applications of fluorescent probes for zinc, ZnAFs. | Hirano, T., et al. 2002. J Am Chem Soc. 124: 6555-62. PMID: 12047174
- Mossy fiber Zn2+ spillover modulates heterosynaptic N-methyl-D-aspartate receptor activity in hippocampal CA3 circuits. | Ueno, S., et al. 2002. J Cell Biol. 158: 215-20. PMID: 12119362
- Ischemic preconditioning decreases intracellular zinc accumulation induced by oxygen-glucose deprivation in gerbil hippocampal CA1 neurons. | Miyawaki, T., et al. 2004. Neurosci Lett. 362: 216-9. PMID: 15158018
- Design and synthesis of zinc-selective chelators for extracellular applications. | Kawabata, E., et al. 2005. J Am Chem Soc. 127: 818-9. PMID: 15656603
- Selective zinc sensor molecules with various affinities for Zn2+, revealing dynamics and regional distribution of synaptically released Zn2+ in hippocampal slices. | Komatsu, K., et al. 2005. J Am Chem Soc. 127: 10197-204. PMID: 16028930
- Inhibition of presynaptic activity by zinc released from mossy fiber terminals during tetanic stimulation. | Minami, A., et al. 2006. J Neurosci Res. 83: 167-76. PMID: 16342122
- Response of hippocampal mossy fiber zinc to excessive glutamate release. | Takeda, A., et al. 2007. Neurochem Int. 50: 322-7. PMID: 17067724
- Negative modulation of presynaptic activity by zinc released from Schaffer collaterals. | Takeda, A., et al. 2007. J Neurosci Res. 85: 3666-72. PMID: 17680671
- Enhancement of hippocampal mossy fiber activity in zinc deficiency and its influence on behavior. | Takeda, A., et al. 2008. Biometals. 21: 545-52. PMID: 18368499
- Attenuation of hippocampal mossy fiber long-term potentiation by low micromolar concentrations of zinc. | Takeda, A., et al. 2008. J Neurosci Res. 86: 2906-11. PMID: 18500762
- Positive modulation of long-term potentiation at hippocampal CA1 synapses by low micromolar concentrations of zinc. | Takeda, A., et al. 2009. Neuroscience. 158: 585-91. PMID: 18984033
- Zinc-mediated attenuation of hippocampal mossy fiber long-term potentiation induced by forskolin. | Ando, M., et al. 2010. Neurochem Int. 57: 608-14. PMID: 20674642
- Influx of extracellular Zn(2+) into the hippocampal CA1 neurons is required for cognitive performance via long-term potentiation. | Takeda, A., et al. 2015. Neuroscience. 304: 209-16. PMID: 26204819
- A fluorogenic probe using a catalytic reaction for the detection of trace intracellular zinc. | Takashima, I., et al. 2020. Chem Commun (Camb). 56: 13327-13330. PMID: 33063059
- Delayed Expression of Both GABABR1 and GABABR2 Subunits in Murine Hippocampal Dentate Gyrus After a Single Systemic Injection of Trimethyltin. | Onishi, Y., et al. 2022. Neurochem Res. 47: 2780-2792. PMID: 35737203
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZnAF-2 DA, 1 mg | sc-202858 | 1 mg | $471.00 |