Date published: 2026-4-25

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ZM 39923 hydrochloride (CAS 1021868-92-7)

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Alternate Names:
3-[(1-Methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-1-propanone hydrochloride
CAS Number:
1021868-92-7
Molecular Weight:
367.91
Molecular Formula:
C23H26ClNO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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ZM 39923 hydrochloride, a synthetic compound extensively utilized in scientific research, acts as a specific agonist for the metabotropic glutamate receptor 5 (mGluR5). With its potent and selective properties, ZM 39923 hydrochloride has been instrumental in investigating the involvement of mGluR5 in various physiological mechanisms. By selectively binding to and activating the ZM 39923 hydrochloride, it initiates downstream signaling pathways that result in diverse physiological effects.


ZM 39923 hydrochloride (CAS 1021868-92-7) References

  1. Structural characterization and high-throughput screening of inhibitors of PvdQ, an NTN hydrolase involved in pyoverdine synthesis.  |  Drake, EJ. and Gulick, AM. 2011. ACS Chem Biol. 6: 1277-86. PMID: 21892836
  2. Regulation of Th1/Th2 polarization by tissue inhibitor of metalloproteinase-3 via modulating dendritic cells.  |  Shao, Q., et al. 2012. Blood. 119: 4636-44. PMID: 22415751
  3. Identification of compounds that modulate retinol signaling using a cell-based qHTS assay.  |  Chen, Y., et al. 2016. Toxicol In Vitro. 32: 287-96. PMID: 26820057
  4. A spleen tyrosine kinase inhibitor attenuates the proliferation and migration of vascular smooth muscle cells.  |  Seo, HH., et al. 2017. Biol Res. 50: 1. PMID: 28100269
  5. Viability Screen of LOPAC1280 Reveals Phosphorylation Inhibitor Auranofin as a Potent Inhibitor of Blastocystis Subtype 1, 4, and 7 Isolates.  |  Yason, JA., et al. 2018. Antimicrob Agents Chemother. 62: PMID: 29866860
  6. EGFR-Aurka Signaling Rescues Polarity and Regeneration Defects in Dystrophin-Deficient Muscle Stem Cells by Increasing Asymmetric Divisions.  |  Wang, YX., et al. 2019. Cell Stem Cell. 24: 419-432.e6. PMID: 30713094
  7. A reactive oxygen species Ca2+ signalling pathway identified from a chemical screen for modifiers of sugar-activated circadian gene expression.  |  Li, X., et al. 2022. New Phytol. 236: 1027-1041. PMID: 35842791

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

ZM 39923 hydrochloride, 10 mg

sc-474395
10 mg
$330.00