Molecular structure of ZM 323881 hydrochloride, CAS Number: 324077-30-7
ZM 323881 hydrochloride (CAS 324077-30-7)
See product citations (1)
Alternate Names:
4-Fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]phenol Hydrochloride
Application:
ZM 323881 hydrochloride is a receptor tyrosine kinase inhibitor of VEGFR-2 (Flk-1), PDGFR-beta, EGFR, and FGFR1
CAS Number:
324077-30-7
Molecular Weight:
411.86
Molecular Formula:
C22H18FN3O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ZM 323881 hydrochloride is a potent and selective inhibitor of human Flk-1 (vascular endothelial growth factor receptor 2, VEGFR-2/KDR) activity. ZM 323881 hydrochloride inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC50 = 8 nM). Selectively inhibits Flk-1 (VEGFR-2) (IC50 = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases. ZM 323881 hydrochloride is an inhibitor of EGFR, Flg and PDGFR-β.
ZM 323881 hydrochloride (CAS 324077-30-7) References
Whittles et al (2002) ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity. Microcirculation 9 513. Endo et al (2003) Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF. J.Recept.Signal Transduct.Res. 23 239.Inhibitor of:
EGFR, Flg, Flk-1, PDGFR-beta, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZM 323881 hydrochloride, 1 mg | sc-296861 | 1 mg | $105.00 | |||
ZM 323881 hydrochloride, 10 mg | sc-296861A | 10 mg | $164.00 |