Date published: 2025-12-11

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ZM-323881 (CAS 193001-14-8)

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Alternate Names:
N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-ethyl)quinoline-3-carboxamide, VU0285655-1
CAS Number:
193001-14-8
Molecular Weight:
375.4
Molecular Formula:
C22H18FN3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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ZM-323881 is extensively employed in biological research, specifically in studies related to angiogenesis and vascular biology. This compound is recognized for its ability to selectively inhibit vascular endothelial growth factor receptor-2 (VEGFR-2), which plays a pivotal role in the process of blood vessel formation. Researchers use ZM-323881 to investigate the signaling pathways involved in endothelial cell proliferation and migration. This is for understanding the mechanisms of angiogenesis under both normal and pathological conditions. Additionally, ZM-323881 is used in studies aiming to delineate the molecular interactions and effects of kinase inhibition in various cellular processes related to vascular development and function.


ZM-323881 (CAS 193001-14-8) References

  1. Angiotensin II increases the permeability and PV-1 expression of endothelial cells.  |  Bodor, C., et al. 2012. Am J Physiol Cell Physiol. 302: C267-76. PMID: 22012329
  2. VEGFR2 signalling contributes to increased endothelial susceptibility to TNF-α under chronic non-uniform shear stress.  |  Urschel, K., et al. 2011. Atherosclerosis. 219: 499-509. PMID: 22019447
  3. Lactate engages receptor tyrosine kinases Axl, Tie2, and vascular endothelial growth factor receptor 2 to activate phosphoinositide 3-kinase/Akt and promote angiogenesis.  |  Ruan, GX. and Kazlauskas, A. 2013. J Biol Chem. 288: 21161-21172. PMID: 23754286
  4. Bone marrow-derived mesenchymal stem cells drive lymphangiogenesis.  |  Maertens, L., et al. 2014. PLoS One. 9: e106976. PMID: 25222747
  5. NHERF1 regulates the progression of colorectal cancer through the interplay with VEGFR2 pathway.  |  Gu, Y., et al. 2017. Oncotarget. 8: 7753-7765. PMID: 27999191
  6. Endothelial cell regulation of salivary gland epithelial patterning.  |  Kwon, HR., et al. 2017. Development. 144: 211-220. PMID: 28096213
  7. The Different Effects of VEGFA121 and VEGFA165 on Regulating Angiogenesis Depend on Phosphorylation Sites of VEGFR2.  |  Shiying, W., et al. 2017. Inflamm Bowel Dis. 23: 603-616. PMID: 28296822
  8. Dickkopf-3 Upregulates VEGF in Cultured Human Endothelial Cells by Activating Activin Receptor-Like Kinase 1 (ALK1) Pathway.  |  Busceti, CL., et al. 2017. Front Pharmacol. 8: 111. PMID: 28352232
  9. Antimicrobial ceragenins inhibit biofilms and affect mammalian cell viability and migration in vitro.  |  Olekson, MA., et al. 2017. FEBS Open Bio. 7: 953-967. PMID: 28680809
  10. Identification and characterization of agnuside, a natural proangiogenic small molecule.  |  Pillarisetti, P. and Myers, KA. 2018. Eur J Med Chem. 160: 193-206. PMID: 30340142
  11. Bladder cancer cells interact with vascular endothelial cells triggering EGFR signals to promote tumor progression.  |  Huang, Z., et al. 2019. Int J Oncol. 54: 1555-1566. PMID: 30816487
  12. Pro-angiogenic Activity Discriminates Human Adipose-Derived Stromal Cells From Retinal Pericytes: Considerations for Cell-Based Therapy of Diabetic Retinopathy.  |  Kremer, H., et al. 2020. Front Cell Dev Biol. 8: 387. PMID: 32582693
  13. VEGF is an autocrine/paracrine neuroprotective factor for injured retinal ganglion neurons.  |  Froger, N., et al. 2020. Sci Rep. 10: 12409. PMID: 32710087

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

ZM-323881, 1 mg

sc-471113
1 mg
$73.00