ZLJ-6 (CAS 1051931-39-5)
Alternate Names:
(5Z)-2-amino-1,5-dihydro-1-methyl-5-[[4-(methylsulfonyl)phenyl]methylene]-4H-imidazol-4-one, monomethanesulfonate
Application:
ZLJ-6 is an inhibitor of Cox-1, Cox-2, and 5-LO
CAS Number:
1051931-39-5
Molecular Weight:
375.4
Molecular Formula:
C12H13N3O3S•CH3SO3H
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
ZLJ-6 is an inhibitor of Cox-1 (cyclooxygenase-1) (IC50 = 0.73 μM), Cox-2 (IC50 = 0.31 μM), and 5-LO (5-lipoxygenase) (IC50 = 0.99 μM). ZLJ-6 reduces carrageenin-induced paw edema (inflammation) in rats and acetic acid-induced abdominal constriction (pain) in mice without causing gastrointestinal ulcers, a common side effect of non-selective Cox inhibitors.
References
1 Li, L., Ji, H., Sheng, L., et al. The anti-inflammatory effects of ZLJ-6, a novel dual cyclooxygenase/5-lipoxygenase inhibitor. Eur J Pharmacol 607 (1-3) 244-250 (2009).
Physical State
:
Solid
Storage
:
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID
:
SMILES
:
CN1/C(=C\C2=CC=C(C=C2)S(=O)(=O)C)/C(=O)N=C1N.CS(=O)(=O)O
Download SDS (MSDS)
Certificate of Analysis
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