ZLJ-6 CAS: 1051931-39-5
MF: C12H13N3O3S•CH3SO3H
MW: 375.4
An inhibitor of Cox-1, Cox-2, and 5-LO.

ZLJ-6 (CAS 1051931-39-5)

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Alternate Names: (5Z)-2-amino-1,5-dihydro-1-methyl-5-[[4-(methylsulfonyl)phenyl]methylene]-4H-imidazol-4-one, monomethanesulfonate
Application: ZLJ-6 is an inhibitor of Cox-1, Cox-2, and 5-LO
CAS Number: 1051931-39-5
Molecular Weight: 375.4
Molecular Formula: C12H13N3O3S•CH3SO3H
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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ZLJ-6 is an inhibitor of Cox-1 (cyclooxygenase-1) (IC50 = 0.73 μM), Cox-2 (IC50 = 0.31 μM), and 5-LO (5-lipoxygenase) (IC50 = 0.99 μM). ZLJ-6 reduces carrageenin-induced paw edema (inflammation) in rats and acetic acid-induced abdominal constriction (pain) in mice without causing gastrointestinal ulcers, a common side effect of non-selective Cox inhibitors.


References

1 Li, L., Ji, H., Sheng, L., et al. The anti-inflammatory effects of ZLJ-6, a novel dual cyclooxygenase/5-lipoxygenase inhibitor. Eur J Pharmacol 607 (1-3) 244-250 (2009).

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
CN1/C(=C\C2=CC=C(C=C2)S(=O)(=O)C)/C(=O)N=C1N.CS(=O)(=O)O

Download SDS (MSDS)

Certificate of Analysis

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