Molecular structure of ZLJ-6, CAS Number: 1051931-39-5
ZLJ-6 (CAS 1051931-39-5)
Alternate Names:
(5Z)-2-amino-1,5-dihydro-1-methyl-5-[[4-(methylsulfonyl)phenyl]methylene]-4H-imidazol-4-one, monomethanesulfonate
Application:
ZLJ-6 is an inhibitor of Cox-1, Cox-2, and 5-LO
CAS Number:
1051931-39-5
Molecular Weight:
375.4
Molecular Formula:
C12H13N3O3S•CH3SO3H
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ZLJ-6 is an inhibitor of Cox-1 (cyclooxygenase-1) (IC50 = 0.73 μM), Cox-2 (IC50 = 0.31 μM), and 5-LO (5-lipoxygenase) (IC50 = 0.99 μM). ZLJ-6 reduces carrageenin-induced paw edema (inflammation) in rats and acetic acid-induced abdominal constriction (pain) in mice without causing gastrointestinal ulcers, a common side effect of non-selective Cox inhibitors.
ZLJ-6 (CAS 1051931-39-5) References
- The anti-inflammatory effects of ZLJ-6, a novel dual cyclooxygenase/5-lipoxygenase inhibitor. | Li, L., et al. 2009. Eur J Pharmacol. 607: 244-50. PMID: 19243697
- ZLJ-6, a novel COX/5-LOX inhibitor, attenuates TNF-α-induced endothelial E-selectin, ICAM-1 and VCAM-1 expression and monocyte-endothelial interactions via a COX/5-LOX-independent mechanism. | Chen, L., et al. 2011. Vascul Pharmacol. 55: 135-42. PMID: 21777697
Inhibitor of:
5-LO, Cox-2, and CSN6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZLJ-6, 1 mg | sc-224468 | 1 mg | $40.00 | |||
ZLJ-6, 5 mg | sc-224468A | 5 mg | $180.00 |