Molecular structure of ZK118182 isopropyl ester, CAS Number: 154927-31-8
ZK118182 isopropyl ester (CAS 154927-31-8)
Alternate Names:
[[4- [5R- chloro- 2Z- [3R- cyclohexyl- 3S- hydroxy- 1R- propenyl]- 3S- hydroxycyclopentyl]- 2R- butenyl]oxy]- acetic acid isopropyl ester
Application:
ZK118182 isopropyl ester is a PG analog that shows potent DP-agonist activity
CAS Number:
154927-31-8
Molecular Weight:
429.0
Molecular Formula:
C23H37ClO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF2α and PGD2, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki = 74 nM). ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03 μg, ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid.
ZK118182 isopropyl ester (CAS 154927-31-8) References
- 3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents. | Hellberg, MR., et al. 2002. Bioorg Med Chem. 10: 2031-49. PMID: 11937363
- Molecular pharmacology of the DP/EP2 class prostaglandin AL-6598 and quantitative autoradiographic visualization of DP and EP2 receptor sites in human eyes. | Sharif, NA., et al. 2004. J Ocul Pharmacol Ther. 20: 489-508. PMID: 15684809
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZK118182 isopropyl ester, 100 µg | sc-358886 | 100 µg | $254.00 | |||
ZK118182 isopropyl ester, 500 µg | sc-358886A | 500 µg | $1147.00 |