Molecular structure of ZK 93423 hydrochloride, CAS Number: 83910-44-5
ZK 93423 hydrochloride (CAS 83910-44-5)
Alternate Names:
4-(Methoxymethyl)-6-(phenylmethoxy)-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester hydrochloride
Application:
ZK 93423 hydrochloride is a potent benzodiazepine agonist
CAS Number:
83910-44-5
Molecular Weight:
426.9
Molecular Formula:
C23H22N2O4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ZK 93423 hydrochloride is a potent benzodiazepine agonist. Non-selective with GABAA receptors containing alpha1-, alpha2-, alpha3- and alpha5-subunits. ZK93423 stands as a robust agonist for benzodiazepine receptors with remarkable potency (IC50 = 1 nM). This compound exhibits non-selectivity among GABAA receptors containing α1, α2, α3, and α5 subunits, as reflected in its Ki values: 4.1, 4.2, 6, and 4.5 nM for inhibiting [3H]Ro15-1788 binding to human recombinant α1β3γ2, α2β3γ2, α3β3γ2, and α5β3γ2 receptors, respectively.
ZK 93423 hydrochloride (CAS 83910-44-5) References
- Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. | Huang, Q., et al. 2000. J Med Chem. 43: 71-95. PMID: 10633039
- Benzodiazepine-induced hyperphagia: development and assessment of a 3D pharmacophore by computational methods. | Filizola, M., et al. 2000. J Biomol Struct Dyn. 17: 769-78. PMID: 10798522
- The effects of the benzodiazepine receptor ligand 3-(methoxycarbonyl) amino-beta-carboline on food and water intake in rats. | Patel, SM. and Ebenezer, IS. 2002. Methods Find Exp Clin Pharmacol. 24: 681-3. PMID: 12616961
- New versatile route to the synthesis of tetrahydro-beta-carbolines and tetrahydro-pyrano[3,4-b]indoles via an intramolecular Michael addition catalyzed by InBr3. | Agnusdei, M., et al. 2003. J Org Chem. 68: 7126-9. PMID: 12946165
- Direct and selective functionalization of a tetrahydro-beta-carboline at position 4. | Rannoux, C., et al. 2010. Org Lett. 12: 1240-3. PMID: 20158220
- Easy access to fully functionalized chiral tetrahydro-β-carboline alkaloids. | Arai, T., et al. 2011. J Org Chem. 76: 2909-12. PMID: 21375351
- Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor. | Cho, S., et al. 2014. Psychopharmacology (Berl). 231: 2825-37. PMID: 24488362
- The anxiolytic beta-carboline ZK 93423 prevents the stress-induced increase in dopamine turnover in the prefrontal cortex. | Giorgi, O., et al. 1987. Eur J Pharmacol. 134: 327-31. PMID: 2883014
- Anticonvulsant efficacy of clonazepam and the beta-carboline ZK 93423 during chronic treatment in amygdala-kindled rats. | Löscher, W., et al. 1987. Eur J Pharmacol. 143: 403-14. PMID: 3691663
Substrate of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZK 93423 hydrochloride, 10 mg | sc-204422 | 10 mg | $312.00 | |||
ZK 93423 hydrochloride, 50 mg | sc-204422A | 50 mg | $988.00 |