ZK 756326 CAS: 874911-96-3
MF: C21H28N2O3•2HCl
MW: 429.38
A selective, non-peptide CCR8 chemokine receptor agonist.

ZK 756326 (CAS 874911-96-3)

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Alternate Names: 2-(2-(4-(3-phenoxybenzyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride
Application: ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist
CAS Number: 874911-96-3
Molecular Weight: 429.38
Molecular Formula: C21H28N2O32HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

ZK 756326 is a selective, non-peptide CKR-8 (CCR8 chemokine receptor) agonist (IC50 values are 1.8 and 2.6μM for human and mouse receptors respectively). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion. ZK 756326 displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs.


References

1. Haskell, C.A., et al. 2006. Mol. Pharmacol. 69: 309-316.

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (4 mg/ml).
Storage :
Desiccate at room temperature
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
CKR-8: IC50 = 1.8 µM (human); CKR-8: IC50 = 2.6 µM (mouse)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD09038571
SMILES :
C1CN(CCN1CCOCCO)CC2=CC(=CC=C2)OC3=CC=CC=C3.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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