ZK 756326 is a selective, non-peptide CKR-8 (CCR8 chemokine receptor) agonist (IC50 values are 1.8 and 2.6μM for human and mouse receptors respectively). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion. ZK 756326 displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs.
1. Haskell, C.A., et al. 2006. Mol. Pharmacol. 69: 309-316.
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