Molecular structure of Zinquin, Free Acid, CAS Number: 151606-29-0
Zinquin, Free Acid (CAS 151606-29-0)
See product citations (2)
Alternate Names:
(2-Methyl-8-p-toluenesulfonamido-6-quinolyloxy)acetic acid
Application:
Zinquin, Free Acid is a Zn2+ specific fluorophore that forms zinquin-Zn2+ complexes
CAS Number:
151606-29-0
Purity:
≥98%
Molecular Weight:
386.42
Molecular Formula:
C19H18N2O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Zinquin, Free Acid is a Zn2+ specific fluorophore that forms zinquin-Zn2+ complexes in either 1:1 or 2:1 ratios (Kd of 370 ± 60 nM and 850 ± 160 nM, respectively). Intracellular zinc mobilization may act to be an early indicator of apoptosis. As a zinc probe, it is UV-excitable and emits in the blue region of the spectrum.
Zinquin, Free Acid (CAS 151606-29-0) References
- Fluorescent detection of Zn(2+)-rich vesicles with Zinquin: mechanism of action in lipid environments. | Snitsarev, V., et al. 2001. Biophys J. 80: 1538-46. PMID: 11222314
- Intracellular distribution of labile Zn(II) and zinc transporter expression in kidney and MDCK cells. | Ranaldi, G., et al. 2002. Am J Physiol Renal Physiol. 283: F1365-75. PMID: 12388418
- Coordination and fluorescence of the intracellular Zn2+ probe [2-methyl-8-(4-toluenesulfonamido)-6-quinolyloxy]acetic acid (Zinquin A) in ternary Zn2+ complexes. | Hendrickson, KM., et al. 2003. J Am Chem Soc. 125: 3889-95. PMID: 12656623
- S-Nitroso compounds interfere with zinc probing by Zinquin. | Jansen, S., et al. 2004. Anal Biochem. 332: 145-52. PMID: 15301959
- Zinquin identifies subcellular compartmentalization of zinc in cortical neurons. Relation to the trafficking of zinc and the mitochondrial compartment. | Colvin, RA., et al. 2006. Brain Res. 1085: 1-10. PMID: 16581038
- Reactions of the fluorescent sensor, Zinquin, with the zinc-proteome: adduct formation and ligand substitution. | Nowakowski, AB. and Petering, DH. 2011. Inorg Chem. 50: 10124-33. PMID: 21905645
- Reaction of metal-binding ligands with the zinc proteome: zinc sensors and N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine. | Meeusen, JW., et al. 2012. Inorg Chem. 51: 3625-32. PMID: 22380934
- Sensor specific imaging of proteomic Zn2+ with zinquin and TSQ after cellular exposure to N-ethylmaleimide. | Nowakowski, A. and Petering, D. 2012. Metallomics. 4: 448-56. PMID: 22498931
- Chemical-Biological Properties of Zinc Sensors TSQ and Zinquin: Formation of Sensor-Zn-Protein Adducts versus Zn(Sensor)2 Complexes. | Nowakowski, AB., et al. 2015. Inorg Chem. 54: 11637-47. PMID: 26650477
- Measurement of zinc in hepatocytes by using a fluorescent probe, zinquin: relationship to metallothionein and intracellular zinc. | Coyle, P., et al. 1994. Biochem J. 303 (Pt 3): 781-6. PMID: 7980447
- Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II). | Zalewski, PD., et al. 1993. Biochem J. 296 (Pt 2): 403-8. PMID: 8257431
- Changes in distribution of labile zinc in mouse spermatozoa during maturation in the epididymis assessed by the fluorophore Zinquin. | Zalewski, PD., et al. 1996. Reprod Fertil Dev. 8: 1097-105. PMID: 8916286
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ZIP10.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Zinquin, Free Acid, 5 mg | sc-202387 | 5 mg | $268.00 |