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Zilpaterol (CAS 119520-05-7)

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Alternate Names:
(±)-trans-4,5,6,7-Tetrahydro-7-hydroxy-6-(isopropylamino)imidazo[4,5,1-jk][1]benzazepin-2(1H)-one; RU-42173
Application:
Zilpaterol is a growth promotant and b-andrenergic agonist
CAS Number:
119520-05-7
Purity:
≥95%
Molecular Weight:
261.32
Molecular Formula:
C14H19N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Zilpaterol HCl, chemically known as the hydrochloride salt of zilpaterol, is a synthetic beta-adrenergic agonist distinguished by its potent activity in stimulating the beta-adrenergic receptors within animal tissues. Its mechanism of action hinges on mimicking the effects of adrenaline and noradrenaline, neurotransmitters that play pivotal roles in the fight or flight response, specifically by targeting receptors that mediate physiological responses such as vasodilation and bronchodilation. In research applications, zilpaterol HCl has been extensively studied for its effects on muscle tissue, particularly in understanding its influence on muscle protein synthesis and degradation pathways. The compound′s ability to promote muscle accretion and alter fat deposition offers a valuable model for exploring the intricate balance of anabolic and catabolic processes within muscle physiology. Furthermore, zilpaterol HCl serves as a critical tool in studies aimed at elucidating the molecular mechanisms underpinning beta-adrenergic signaling pathways and their role in tissue development and metabolism. By examining the effects of zilpaterol HCl on these pathways, researchers can gain insights into the regulatory mechanisms that control muscle growth and energy expenditure, contributing to a broader understanding of metabolic regulation and the potential impacts of beta-adrenergic modulation in biological systems.


Zilpaterol (CAS 119520-05-7) References

  1. Extraction, clean-up and gas chromatography-mass spectrometry characterization of zilpaterol as feed additive in fattening cattle.  |  Bocca, B., et al. 2003. J Chromatogr B Analyt Technol Biomed Life Sci. 783: 141-9. PMID: 12450533
  2. Simultaneous determination of Zilpaterol and other beta agonists in calf eye by gas chromatography/tandem mass spectrometry.  |  Bocca, B., et al. 2003. J AOAC Int. 86: 8-14. PMID: 12607734
  3. Enzyme-linked immunosorbent assay development for the beta-adrenergic agonist zilpaterol.  |  Shelver, WL. and Smith, DJ. 2004. J Agric Food Chem. 52: 2159-66. PMID: 15080615
  4. Development of a monoclonal antibody-based enzyme-linked immuosorbent assay for the beta-adrenergic agonist zilpaterol.  |  Shelver, WL., et al. 2005. J Agric Food Chem. 53: 3273-80. PMID: 15853359
  5. Tissue residues and urinary excretion of zilpaterol in sheep treated for 10 days with dietary zilpaterol.  |  Shelver, WL. and Smith, DJ. 2006. J Agric Food Chem. 54: 4155-61. PMID: 16756341
  6. Effects of dietary zilpaterol hydrochloride on feedlot performance and carcass characteristics of beef steers fed with and without monensin and tylosin.  |  Montgomery, JL., et al. 2009. J Anim Sci. 87: 1013-23. PMID: 18997069
  7. Depletion of urinary zilpaterol residues in horses as measured by ELISA and UPLC-MS/MS.  |  Shelver, WL., et al. 2010. J Agric Food Chem. 58: 4077-83. PMID: 20218607
  8. Perspectives on the application of zilpaterol hydrochloride in the United States beef industry.  |  Delmore, RJ., et al. 2010. J Anim Sci. 88: 2825-8. PMID: 20382871
  9. A meta-analysis of zilpaterol and ractopamine effects on feedlot performance, carcass traits and shear strength of meat in cattle.  |  Lean, IJ., et al. 2014. PLoS One. 9: e115904. PMID: 25548908
  10. Simultaneous analysis of spectinomycin, halquinol, zilpaterol, and melamine in feedingstuffs by ion-pair liquid chromatography-tandem mass spectrometry.  |  Molognoni, L., et al. 2018. J Chromatogr A. 1569: 110-117. PMID: 30033166
  11. Detection and quantification of residues in sheep exposed to trace levels of dietary zilpaterol HCl.  |  Smith, DJ., et al. 2019. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 36: 1289-1301. PMID: 31219730
  12. Hypertrophic muscle growth and metabolic efficiency were impaired by chronic heat stress, improved by zilpaterol supplementation, and not affected by ractopamine supplementation in feedlot lambs1.  |  Barnes, TL., et al. 2019. J Anim Sci. 97: 4101-4113. PMID: 31410479
  13. Determination of zilpaterol in a residue depletion study using LC-MS/MS in cattle plasma, muscle, liver and kidney.  |  Dolores-Hernández, M., et al. 2022. Food Chem. 382: 132287. PMID: 35139465
  14. Determination and enantioselective separation of zilpaterol in human urine after mimicking consumption of contaminated meat using high-performance liquid chromatography with tandem mass spectrometry techniques.  |  Euler, L., et al. 2022. Rapid Commun Mass Spectrom. 36: e9357. PMID: 35851724

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Zilpaterol, 5 mg

sc-220402
5 mg
$426.00

Zilpaterol, 10 mg

sc-220402A
10 mg
$724.00

Zilpaterol, 10 mg

sc-220402A-CW
10 mg
$895.00

Zilpaterol, 100 mg

sc-220402B
100 mg
$5732.00

Hello, is there any specific activity per mg that we need to calculate

Asked by: TaraS
Thank you for your question. Unfortunately we are not able to provide this information. Here is a link to the most recent CoA for your convenience: https://datasheets.scbt.com/coa/coa.php?sc=sc-220402&lot=G2518
Answered by: Tech Service
Date published: 2019-06-20
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Rated 5 out of 5 by from ZilpaterolWe are satisfied with the result of this order, thanks
Date published: 2018-03-14
Rated 4 out of 5 by from I will rate this product a 4 and rate 5I will rate this product a 4 and rate 5 for your logistics, customer service and support.
Date published: 2015-04-20
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Zilpaterol is rated 4.5 out of 5 by 2.
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