Zic4 Antibody (RY-6): sc-101202

Zic4 Antibody (RY-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Zic4 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Zic4 antibody (RY-6) is available as the non-conjugated format. Zic4, or zinc finger protein of the cerebellum 4, is a crucial C2H2 zinc finger transcription factor that plays a significant role in cerebellar development, influencing the formation and maturation of cerebellar granule cells. Zic4 is primarily localized in the nuclei of these cells, where Zic4 regulates gene expression essential for proper cerebellar function. Notably, Zic4 mRNA expression peaks on postnatal day 5 in the developing cerebellum of mice, highlighting Zic4′s importance during early brain development. The Zic family of proteins, including Zic4, is vital for various developmental processes and has been implicated in conditions such as X-linked visceral heterotaxy and holoprosencephaly type 5. Additionally, Zic4 is closely linked to Zic1, another family member located on chromosome 3, which further emphasizes the interconnected roles of these transcription factors in developmental biology.

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Zic4 Antibody (RY-6) References:

1. Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter.  |  Salero, E., et al. 2001. J Biol Chem. 276: 1881-8. PMID: 11038359
2. Behavioral abnormalities of Zic1 and Zic2 mutant mice: implications as models for human neurological disorders.  |  Ogura, H., et al. 2001. Behav Genet. 31: 317-24. PMID: 11699604
3. Zic1 represses Math1 expression via interactions with the Math1 enhancer and modulation of Math1 autoregulation.  |  Ebert, PJ., et al. 2003. Development. 130: 1949-59. PMID: 12642498
4. Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation.  |  Grinberg, I., et al. 2004. Nat Genet. 36: 1053-5. PMID: 15338008
5. Identification and characterization of Zic4, a new member of the mouse Zic gene family.  |  Aruga, J., et al. 1996. Gene. 172: 291-4. PMID: 8682319
6. The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation.  |  Nagai, T., et al. 1997. Dev Biol. 182: 299-313. PMID: 9070329

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Zic4 Antibody (RY-6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Zic4 Antibody (RY-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Zic4 Antibody (RY-6) Specifications

Alternate Product Name: Zic4

Product Clone Name: RY-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 249-320

Epitope Target: Zic4

Epitope Species: human

Product Reactivity/Detection: Zic4

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Zic4 Antibody (RY-6): N/A