ZGPAT Antibody (B-3): sc-515524

ZGPAT Antibody (B-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects ZGPAT protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZGPAT (B-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ZGPAT protein, also known as zinc finger CCCH domain-containing protein 9 (ZC3HDC9) and G patch domain-containing protein 6 (GPATC6), is a 531 amino acid protein characterized by the presence of a G-patch domain, which is commonly associated with RNA-binding proteins. This domain is crucial for ZGPAT′s function in RNA processing and regulation, highlighting ZGPAT′s potential role in tumor suppression and DNA damage repair mechanisms. Additionally, ZGPAT contains a C3H1-type zinc finger, further indicating ZGPAT′s involvement in RNA interactions. Notably, the gene encoding ZGPAT is subject to differential methylation in oligodendroglioma cell lines, suggesting ZGPAT′s potential as a biomarker for cancer diagnostics. Furthermore, ZGPAT exists in two isoforms due to alternative splicing, which may contribute to ZGPAT′s functional diversity in cellular processes.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

ZGPAT Antibody (B-3) References:

1. G-patch: a new conserved domain in eukaryotic RNA-processing proteins and type D retroviral polyproteins.  |  Aravind, L. and Koonin, EV. 1999. Trends Biochem Sci. 24: 342-4. PMID: 10470032
2. Identification of ribosomal proteins specific to higher eukaryotic organisms.  |  Gueydan, C., et al. 2002. J Biol Chem. 277: 45034-40. PMID: 12202495
3. Proteinases of betaretroviruses bind single-stranded nucleic acids through a novel interaction module, the G-patch.  |  Svec, M., et al. 2004. FEBS Lett. 576: 271-6. PMID: 15474050
4. The RNA binding G-patch domain in retroviral protease is important for infectivity and D-type morphogenesis of Mason-Pfizer monkey virus.  |  Bauerová-Zábranská, H., et al. 2005. J Biol Chem. 280: 42106-12. PMID: 16257973
5. A CCCH zinc finger conserved in a replication protein a homolog found in diverse Euryarchaeotes.  |  Lin, Y., et al. 2005. J Bacteriol. 187: 7881-9. PMID: 16291661
6. Comprehensive DNA methylation profiling in a human cancer genome identifies novel epigenetic targets.  |  Ordway, JM., et al. 2006. Carcinogenesis. 27: 2409-23. PMID: 16952911
7. Monitoring methylation changes in cancer.  |  Beier, V., et al. 2007. Adv Biochem Eng Biotechnol. 104: 1-11. PMID: 17290816
8. Involvement of G-patch domain containing 2 overexpression in breast carcinogenesis.  |  Lin, ML., et al. 2009. Cancer Sci. 100: 1443-50. PMID: 19432882

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZGPAT Antibody (B-3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ZGPAT Antibody (B-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZGPAT Antibody (B-3) Specifications

Alternate Product Name: ZGPAT

Product Clone Name: B-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 127-254

Epitope Target: ZGPAT

Epitope Species: human

Product Reactivity/Detection: ZGPAT

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ZGPAT Antibody (B-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin