Date published: 2025-10-2

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Zein (CAS 9010-66-6)

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Application:
Zein is a prolamine storage protein in corn that has many applications as a protein based fiber
CAS Number:
9010-66-6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Zein is a prolamine an alcohol-soluble protein present in amounts of 2.5-10% (dry basis) in corn. Zeins are the main storage proteins found in the seeds of maize. Following protein translation, the zeins are stored in the rough endoplasmic reticulum (ER)-derived protein bodies. The accumulation of zein in these ER-derived protein bodies results in the formation of the endosperm - the food storage body of seeds. Currently, there are four classes of zein: alpha, beta, gamma, and delta. These classes are expressed sequentially in maize and are found to interact with each other for stability. Zein from corn was reported to be approximately 35% alpha-zein, which includes 2 prominent bands of 22 and 24 kDa. beta-zein fails to enter an SDS-PAGE gel without reduction. Reducing SDS-PAGE analysis shows that β-zein has 3 major bands of 24, 22, and 14 kDa.


Zein (CAS 9010-66-6) References

  1. Zein-based films and their usage for controlled delivery: Origin, classes and current landscape.  |  Zhang, Y., et al. 2015. J Control Release. 206: 206-19. PMID: 25828699
  2. Design, fabrication and biomedical applications of zein-based nano/micro-carrier systems.  |  Zhang, Y., et al. 2016. Int J Pharm. 513: 191-210. PMID: 27615709
  3. Zein-based Nanocarriers as Potential Natural Alternatives for Drug and Gene Delivery: Focus on Cancer Therapy.  |  Elzoghby, A., et al. 2017. Curr Pharm Des. 23: 5261-5271. PMID: 28641543
  4. Overview on zein protein: a promising pharmaceutical excipient in drug delivery systems and tissue engineering.  |  Labib, G. 2018. Expert Opin Drug Deliv. 15: 65-75. PMID: 28662354
  5. Zein as a Pharmaceutical Excipient in Oral Solid Dosage Forms: State of the Art and Future Perspectives.  |  Berardi, A., et al. 2018. AAPS PharmSciTech. 19: 2009-2022. PMID: 29736888
  6. The use of zein in the controlled release of poorly water-soluble drugs.  |  Tran, PHL., et al. 2019. Int J Pharm. 566: 557-564. PMID: 31181306
  7. Design of Zein Conjugation and Surface Modification for Targeting Drug Delivery.  |  Tran, PH. and Tran, TT. 2020. Curr Drug Targets. 21: 406-415. PMID: 31518220
  8. Formation and Characterization of Zein-Based Oleogels.  |  Tsung, KL., et al. 2020. J Agric Food Chem. 68: 13276-13281. PMID: 33047955
  9. Development of a nanoparticle delivery system based on zein/polysaccharide complexes.  |  Li, M. and Yu, M. 2020. J Food Sci. 85: 4108-4117. PMID: 33249573
  10. Zein-induced immune response and modulation by size, pore structure and drug-loading: Application for sciatic nerve regeneration.  |  Yu, J., et al. 2022. Acta Biomater. 140: 289-301. PMID: 34843952
  11. Zein enhanced the digestive stability of five citrus flavonoids via different binding interaction.  |  Li, W., et al. 2022. J Sci Food Agric. 102: 4780-4790. PMID: 35218206
  12. Application of zein in gluten-free foods: A comprehensive review.  |  Zhang, Y., et al. 2022. Food Res Int. 160: 111722. PMID: 36076416
  13. Zein nanoparticles for drug delivery: Preparation methods and biological applications.  |  André de Almeida Campos, L., et al. 2023. Int J Pharm. 635: 122754. PMID: 36812950

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Zein, 500 g

sc-216069
500 g
$133.00

Zein, 1 kg

sc-216069A
1 kg
$194.00

Zein, 5 kg

sc-216069B
5 kg
$707.00