Molecular structure of ZD 7288, CAS Number: 133059-99-1
ZD 7288 (CAS 133059-99-1)
Alternate Names:
ICI-D 7288; N-Ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine Hydrochloride
Application:
ZD 7288 is an inhibitor of Ih & the hyperpolarization activated cation current If
CAS Number:
133059-99-1
Molecular Weight:
292.81
Molecular Formula:
C15H21N4•Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ZD 7288 has been reported to block Ih in central neurons, and inhibit the hyperpolarization activated cation current If. ZD 7288 is an effective modulator of sino-atrial node function that acts by blocking the hyperpolarization-activated cation current If, which is mediated by HCN channels. It also inhibits Ih in central neurons and exerts an inhibitory effect on synaptic transmission. In addition, ZD 7288 demonstrates selective inhibition of the Ih channel. Furthermore, it has been observed to enhance the release of noradrenaline in rat brain tissue in vitro when NMDA is present.
ZD 7288 (CAS 133059-99-1) References
- The role of the hyperpolarization-activated current in modulating rhythmic activity in the isolated respiratory network of mice. | Thoby-Brisson, M., et al. 2000. J Neurosci. 20: 2994-3005. PMID: 10751452
- Modulation of the hyperpolarisation-activated current, Ih, in rat facial motoneurones in vitro by ZD-7288. | Larkman, PM. and Kelly, JS. 2001. Neuropharmacology. 40: 1058-72. PMID: 11406198
- Contribution of the hyperpolarization-activated current (I(h)) to membrane potential and GABA release in hippocampal interneurons. | Lupica, CR., et al. 2001. J Neurophysiol. 86: 261-8. PMID: 11431507
- Peripheral block of the hyperpolarization-activated cation current (Ih) reduces mechanical allodynia in animal models of postoperative and neuropathic pain. | Dalle, C. and Eisenach, JC. 2005. Reg Anesth Pain Med. 30: 243-8. PMID: 15898027
- Hyperpolarization-activated cation channels in fast-spiking interneurons of rat hippocampus. | Aponte, Y., et al. 2006. J Physiol. 574: 229-43. PMID: 16690716
- Molecular regulation and pharmacology of pacemaker channels. | Bois, P., et al. 2007. Curr Pharm Des. 13: 2338-49. PMID: 17692005
- ZD 7288 inhibits T-type calcium current in rat hippocampal pyramidal cells. | Sánchez-Alonso, JL., et al. 2008. Neurosci Lett. 439: 275-80. PMID: 18534748
- HCN pacemaker channels and pain: a drug discovery perspective. | Wickenden, AD., et al. 2009. Curr Pharm Des. 15: 2149-68. PMID: 19519450
- Dopamine modulates the off pathway in light-adapted mouse retina. | Yang, J., et al. 2013. J Neurosci Res. 91: 138-50. PMID: 23023788
- Regulation of epileptiform discharges in rat neocortex by HCN channels. | Albertson, AJ., et al. 2013. J Neurophysiol. 110: 1733-43. PMID: 23864381
- ZD 7288, an HCN channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats. | Chen, Y., et al. 2014. World J Gastroenterol. 20: 2091-7. PMID: 24587682
- Effects of the bradycardic agent ZD 7288 on membrane voltage and pacemaker current in sheep cardiac Purkinje fibres. | Berger, F., et al. 1994. Naunyn Schmiedebergs Arch Pharmacol. 350: 677-84. PMID: 7708125
- Mechanism of block by ZD 7288 of the hyperpolarization-activated inward rectifying current in guinea pig substantia nigra neurons in vitro. | Harris, NC. and Constanti, A. 1995. J Neurophysiol. 74: 2366-78. PMID: 8747199
- Variation in effects of Cs+, UL-FS-49, and ZD-7288 within sinoatrial node. | Nikmaram, MR., et al. 1997. Am J Physiol. 272: H2782-92. PMID: 9227558
- Action of the hyperpolarization-activated current (Ih) blocker ZD 7288 in hippocampal CA1 neurons. | Gasparini, S. and DiFrancesco, D. 1997. Pflugers Arch. 435: 99-106. PMID: 9359908
Inhibitor of:
OR4C46, Vmn2r47, and Vmn2r57.Activator of:
Potassium Chloride.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZD 7288, 10 mg | sc-361419 | 10 mg | $211.00 | |||
ZD 7288, 50 mg | sc-361419A | 50 mg | $552.00 |