Molecular structure of Zardaverine, CAS Number: 101975-10-4
Zardaverine (CAS 101975-10-4)
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Application:
Zardaverine is a pyridazinone derivative and a selective inhibitor of phosphodiesterase type III and IV
CAS Number:
101975-10-4
Purity:
≥98%
Molecular Weight:
268.2
Molecular Formula:
C12H10F2N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Zardaverine is widely used in biochemical research focused on the study of cyclic nucleotide phosphodiesterases (PDEs). This chemical specifically inhibits PDE3 and PDE4, enzymes critical for the breakdown of cAMP and cGMP, which are important molecules in cellular signaling pathways. By inhibiting these enzymes, Zardaverine helps researchers understand the role of cAMP and cGMP in various cellular processes, including inflammation, cell proliferation, and apoptosis. The use of Zardaverine in these studies provides insights into the molecular mechanisms that regulate cell function and survival. Furthermore, Zardaverine is employed in research exploring the signaling pathways involved in immune responses and has proven instrumental in studies related to cellular response to different environmental stimuli.
Zardaverine (CAS 101975-10-4) References
- Possible Contribution of Prostaglandin E2 to the antiproliferative effect of phosphodiesterase 4 inhibitors in human mononuclear cells. | Banner, KH., et al. 1999. Biochem Pharmacol. 58: 1487-95. PMID: 10513992
- Zardaverine and aerosolised iloprost in a model of acute respiratory failure. | Schermuly, RT., et al. 2003. Eur Respir J. 22: 342-7. PMID: 12952271
- Zardaverine as a selective inhibitor of phosphodiesterase isozymes. | Schudt, C., et al. 1991. Biochem Pharmacol. 42: 153-62. PMID: 1648920
- Actions of the phosphodiesterase inhibitor zardaverine on guinea-pig ventricular muscle. | Galvan, M. and Schudt, C. 1990. Naunyn Schmiedebergs Arch Pharmacol. 342: 221-7. PMID: 1700309
- Phosphodiesterase 3/4 inhibitor zardaverine exhibits potent and selective antitumor activity against hepatocellular carcinoma both in vitro and in vivo independently of phosphodiesterase inhibition. | Sun, L., et al. 2014. PLoS One. 9: e90627. PMID: 24598942
- Targeting tumor cells based on Phosphodiesterase 3A expression. | Nazir, M., et al. 2017. Exp Cell Res. 361: 308-315. PMID: 29107068
- A Dual Phosphodiesterase Inhibitor, Zardaverine (Type 3/4), Enhances Motility of Frozen-thawed Boar Sperm. | Jeong, J., et al. 2018. Cryo Letters. 39: 196-200. PMID: 30059566
- Insights into the potential of withanolides as Phosphodiesterase-4 (PDE4D) inhibitors. | Rathi, A., et al. 2023. J Biomol Struct Dyn. 41: 2108-2117. PMID: 35060432
- Hydrogen peroxide-induced increase in lung endothelial and epithelial permeability--effect of adenylate cyclase stimulation and phosphodiesterase inhibition. | Seeger, W., et al. 1995. Microvasc Res. 50: 1-17. PMID: 7476570
- Comparative investigation of the effects of zardaverine and theophylline on pulmonary function in rats. | Hoymann, HG., et al. 1994. Exp Lung Res. 20: 235-50. PMID: 7925141
- Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs. | Underwood, DC., et al. 1994. J Pharmacol Exp Ther. 270: 250-9. PMID: 8035322
- The specific type III and IV phosphodiesterase inhibitor zardaverine suppresses formation of tumor necrosis factor by macrophages. | Schade, FU. and Schudt, C. 1993. Eur J Pharmacol. 230: 9-14. PMID: 8381357
- Protection by phosphodiesterase inhibitors against endotoxin-induced liver injury in galactosamine-sensitized mice. | Fischer, W., et al. 1993. Biochem Pharmacol. 45: 2399-404. PMID: 8392340
Inhibitor of:
GPR161, LOC642781, Olfr1178, PDE, PDE 3A, PDE1A, PDE4A, and PDE4C.Activator of:
α-protein kinase 3, β-sarcoglycan, AKAP 9, ANKRD31, APOBEC4, Arbp, ARMC4, ARRDC2, ATP6E, BCNP1, C4BPα, cAMP-GEFII, CapZIP, CASC1, CAT56, CCDC124, CCDC84, CCDC85B, CCDC97, CHSY2, CPSF6, CRISP-2, CSDA, CYP21A2, Cypher, Cypt2, Epsilon-COP, GALR1, Gas7, GC kinase, GDE6, GPR3, H2-T10, HEATR7B2, ICAM-3, IGFL1, KIF18B, KKIAMRE, laeverin_4833403I15Rik, LHR, LTH-A, Ly6g, MADP-1, MFF, MOBKL2A, MPP3, MSG1, nardilysin, NELL2, NOP9, NRIP3, NRK, NUDT3, Olfr1054, OR1A2, PC1, PCTAIRE-3, PDE1C, PDE3A, PHACTR1, PKA IIβ reg, PKDCC, PNRC1, PTG, PYST2, Ramp4, Rap 2C, RNase 13, RRP12, Synaptogyrin-3, TALK-2, TCEAL2, TFIIIC220, TMEM216, TMEM233, UPase, V-ATPase G3, VCY1B, VWA5A, and ZCCHC5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Zardaverine, 5 mg | sc-201208 | 5 mg | $88.00 | |||
Zardaverine, 25 mg | sc-201208A | 25 mg | $379.00 |