Molecular structure of Zaragozic acid A trisodium salt, CAS Number: 144541-82-2
Zaragozic acid A trisodium salt (CAS 144541-82-2)
See product citations (2)
Alternate Names:
Zaragozic acid A is also known as Squalestatin A, Squalestatin S1, and L 694599.
Application:
Zaragozic acid A trisodium salt is a potent inhibitor of squalene synthase. It has been used as a cholesterol synthesis inhibitor in T cells.
CAS Number:
144541-82-2
Purity:
>95%
Molecular Weight:
756.68
Molecular Formula:
C35H43Na3O14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Zaragozic acid A trisodium salt is a potent inhibitor of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Being a squalene synthase inhibitor, Zaragozic acid A trisodium salt may produce lower plasma cholesterol levels in primates. We offer also offer the free acid form, Zaragozic Acid A (sc-391058), to avoid stability problems associated with hydrolysis of the salt.
Zaragozic acid A trisodium salt (CAS 144541-82-2) References
- Transcriptional regulation of the squalene synthase gene (ERG9) in the yeast Saccharomyces cerevisiae. | Kennedy, MA., et al. 1999. Biochim Biophys Acta. 1445: 110-22. PMID: 10209263
- Upregulation of sterol C14-demethylase expression in Trypanosoma cruzi treated with sterol biosynthesis inhibitors. | Hankins, EG., et al. 2005. Mol Biochem Parasitol. 144: 68-75. PMID: 16165233
- Systematic exploration of essential yeast gene function with temperature-sensitive mutants. | Li, Z., et al. 2011. Nat Biotechnol. 29: 361-7. PMID: 21441928
- Identification of a New Cholesterol-Binding Site within the IFN-γ Receptor that is Required for Signal Transduction. | Morana, O., et al. 2022. Adv Sci (Weinh). 9: e2105170. PMID: 35166455
- Statins as Potential Preventative Treatment of ETX and Multiple Pore-Forming Toxin-Induced Diseases. | Huang, J., et al. 2023. Int J Mol Sci. 24: PMID: 36982489
- Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase. | Bergstrom, JD., et al. 1993. Proc Natl Acad Sci U S A. 90: 80-4. PMID: 8419946
- Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase. | Bergstrom, JD., et al. 1995. Annu Rev Microbiol. 49: 607-39. PMID: 8561474
- Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A. | Vaidya, S., et al. 1998. Arch Biochem Biophys. 355: 84-92. PMID: 9647670
- HMG-CoA reductase regulation: use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator production in cultured IM-9 cells. | Petras, SF., et al. 1999. J Lipid Res. 40: 24-38. PMID: 9869647
Inhibitor of:
Squalene synthetase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Zaragozic acid A trisodium salt, 5 mg | sc-302001 | 5 mg | $710.00 |