Molecular structure of ZAPA sulfate, CAS Number: 92138-10-8
ZAPA sulfate (CAS 92138-10-8)
Alternate Names:
Z-3-(Amidinothio)propenoic acid sulfate
Application:
ZAPA sulfate is a selective potent GABAA receptor agonist
CAS Number:
92138-10-8
Purity:
98%
Molecular Weight:
244.2
Molecular Formula:
C4H6N2O2S•H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
ZAPA is an isothiouronium analogue of gamma-aminobutyric acid (GABA) and a selective agonist of the low affinity GABAA receptor. Derivatives of ZAPA were studied for GABAA agonist activity and ZAPA, containing what is shown to be a cis-double bond, demonstrated the highest affinity of its derivatives. ZAPA also shows higher affinity at GABAA than both the potent agonist muscimol (sc-200460) and GABA (sc-203053) itself. Perturbation of the GABAA system by chemicals such as ZAPA allows elucidation of its functions and presents an avenue of chemical intervention into neuronal signaling.
ZAPA sulfate (CAS 92138-10-8) References
- GABAA agonists as targets for drug development. | Johnston, GA. 1992. Clin Exp Pharmacol Physiol. 19: 73-8. PMID: 1320473
- Sodium and water intake are not affected by GABAC receptor activation in the lateral parabrachial nucleus of sodium-depleted rats. | Domingos-Souza, G., et al. 2016. J Chem Neuroanat. 74: 47-54. PMID: 26970564
- ZAPA, (Z)-3-[(aminoiminomethyl)thio]-2-propenoic acid hydrochloride, a potent agonist at GABA-receptors on the Ascaris muscle cell. | Holden-Dye, L. and Walker, RJ. 1988. Br J Pharmacol. 95: 3-5. PMID: 2851353
- Isothiouronium compounds as gamma-aminobutyric acid agonists. | Allan, RD., et al. 1986. Br J Pharmacol. 88: 379-87. PMID: 3015310
- Developmental regulation of regional functionality of substantial nigra GABAA receptors involved in seizures. | Velísková, J., et al. 1996. Eur J Pharmacol. 309: 167-73. PMID: 8874135
- Structural analogues of ZAPA as GABAA agonists. | Allan, RD., et al. 1997. Neurochem Int. 30: 583-91. PMID: 9153000
- Properties of GABA(A) receptors in cultured rat oligodendrocyte progenitor cells. | Williamson, AV., et al. 1998. Neuropharmacology. 37: 859-73. PMID: 9776382
Inhibitor of:
Gab 1.Activator of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZAPA sulfate, 5 mg | sc-200471 | 5 mg | $72.00 |