Zanamivir Amine Triacetate Methyl Ester (CAS 139110-70-6)

Zanamivir Amine Triacetate Methyl Ester is a derivative of zanamivir, one of the neuraminidase inhibitors used to study influenza virus mechanisms in non-therapeutic research settings. This compound, specifically designed for research use, features the core structure of zanamivir but is modified with an amine triacetate methyl ester group to enhance its solubility and reactivity in biochemical assays. The compound′s primary action in scientific studies is related to its interaction with the neuraminidase enzyme of the influenza virus. Neuraminidase plays a crucial role in the viral life cycle, facilitating the release of new virus particles from infected host cells. Zanamivir Amine Triacetate Methyl Ester serves as an inhibitor of this enzyme, allowing researchers to study the process of viral replication and release in detail. By binding to the active site of neuraminidase, Zanamivir Amine Triacetate Methyl Ester prevents the cleavage of sialic acid residues, a critical step needed for the liberation of new viral particles. This blockage is instrumental in studying the virus′s propagation mechanisms and exploring how inhibition of neuraminidase affects the overall viral life cycle. In research contexts, this compound is particularly valuable for probing the biochemical pathways and mutation-related changes in the neuraminidase enzyme. Scientists use it to investigate how different mutations in the neuraminidase sequence alter the enzyme′s susceptibility to inhibitors, which is crucial for understanding resistance mechanisms and guiding the development of more effective antiviral agents.