Zafirlukast (CAS 107753-78-6)
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Zafirlukast is a selective leukotriene receptor antagonist that has become a subject of interest in research concerning the regulation of leukotrienes, which are inflammatory mediators. In experimental models, zafirlukast is used to investigate the broader role of leukotrienes in inflammatory responses, as well as their contribution to bronchoconstriction and airway hyper-responsiveness. The compound′s ability to bind to cysteinyl leukotriene receptors makes it a key tool for understanding how these receptors mediate various immune and inflammatory processes. Further, it is involved in research focusing on the chronic inflammation seen in respiratory diseases, aiding in the elucidation of the complex interplay between inflammatory cells and mediators. In addition to respiratory research, zafirlukast is also studied in the context of its effects on other biological systems where leukotrienes play a role, such as in allergic reactions and certain cardiovascular conditions.
Zafirlukast (CAS 107753-78-6) References
- Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of zafirlukast, a selective leukotriene antagonist in human plasma: application to a clinical pharmacokinetic study. | Bharathi, DV., et al. 2008. Biomed Chromatogr. 22: 645-53. PMID: 18254142
- The preventive effect of topical zafirlukast instillation for peri-implant capsule formation in rabbits. | Kang, SH., et al. 2015. Arch Plast Surg. 42: 179-85. PMID: 25798389
- Zafirlukast and vincamine ameliorate tamoxifen-induced oxidative stress and inflammation: Role of the JNK/ERK pathway. | El-Dessouki, AM., et al. 2018. Life Sci. 202: 78-88. PMID: 29626531
- Zafirlukast promotes insulin secretion by increasing calcium influx through L-type calcium channels. | Hwang, HJ., et al. 2018. J Cell Physiol. 233: 8701-8710. PMID: 29797580
- Zafirlukast in combination with pseudohypericin attenuates spinal cord injury and motor function in experimental mice. | Chen, XG., et al. 2018. Drug Des Devel Ther. 12: 2389-2402. PMID: 30122897
- Cysteinyl leukotriene receptor type 1 (CysLT1R) antagonist zafirlukast protects against TNF-α-induced endothelial inflammation. | Zhou, X., et al. 2019. Biomed Pharmacother. 111: 452-459. PMID: 30594784
- Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ. | Göbel, T., et al. 2019. Front Pharmacol. 10: 263. PMID: 30949053
- Antineoplastic properties of zafirlukast against hepatocellular carcinoma via activation of mitochondrial mediated apoptosis. | Kumar, P., et al. 2019. Regul Toxicol Pharmacol. 109: 104489. PMID: 31605713
- Quantitative single-molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα-induced NF-ĸB signaling. | Weinelt, N., et al. 2021. J Leukoc Biol. 109: 363-371. PMID: 32401398
- Zafirlukast is a broad-spectrum thiol isomerase inhibitor that inhibits thrombosis without altering bleeding times. | Holbrook, LM., et al. 2021. Br J Pharmacol. 178: 550-563. PMID: 33080041
- Zafirlukast promotes mitochondrial respiration by stimulating mitochondrial biogenesis in human bronchial epithelial cells. | Ren, P., et al. 2021. J Mol Histol. 52: 643-650. PMID: 33977464
- Zafirlukast inhibits the growth of lung adenocarcinoma via inhibiting TMEM16A channel activity. | Shi, S., et al. 2022. J Biol Chem. 298: 101731. PMID: 35176281
- The spike-ACE2 binding assay: An in vitro platform for evaluating vaccination efficacy and for screening SARS-CoV-2 inhibitors and neutralizing antibodies. | Zhang, S., et al. 2022. J Immunol Methods. 503: 113244. PMID: 35218866
- Zafirlukast Induces VHL- and HIF-2α-Dependent Oxidative Cell Death in 786-O Clear Cell Renal Carcinoma Cells. | Wolf, C., et al. 2022. Int J Mol Sci. 23: PMID: 35408930
- Effects of the cysteinyl leukotriene receptor antagonists pranlukast and zafirlukast on tracheal mucus secretion in ovalbumin-sensitized guinea-pigs in vitro. | Liu, YC., et al. 1998. Br J Pharmacol. 124: 563-71. PMID: 9647482
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Zafirlukast, 10 mg | sc-204942 | 10 mg | $37.00 | |||
Zafirlukast, 100 mg | sc-204942A | 100 mg | $174.00 |