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Zacopride hydrochloride (CAS 101303-98-4)

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Alternate Names:
(±)-4-Amino-N-1-azabicyclo[2.2.2]oct -3-yl-5-chloro-2-methoxybenzamide hydrochloride
Application:
Zacopride hydrochloride is a highly potent SR-3 antagonist and SR-4 agonist
CAS Number:
101303-98-4
Purity:
≥98%
Molecular Weight:
346.25
Molecular Formula:
C15H20ClN3O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Zacopride hydrochloride is a selective antagonist of the serotonin receptor subtype 5-HT3. It acts by binding to the receptor and inhibiting its activity, thereby blocking the effects of serotonin at this specific receptor. This interaction prevents the opening of ion channels, leading to a decrease in the transmission of signals in the central and peripheral nervous systems. By modulating the activity of the 5-HT3 receptor, Zacopride hydrochloride may influence various physiological processes and behaviors that are regulated by serotonin, such as mood, cognition, and gastrointestinal function. Its mechanism of action involves disrupting the binding of serotonin to the receptor, thereby altering the downstream signaling pathways and cellular responses. In experimental applications, Zacopride hydrochloride is used to investigate the specific role of the 5-HT3 receptor in various biological processes.


Zacopride hydrochloride (CAS 101303-98-4) References

  1. Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT4 receptor versus human 5-HT3 receptor.  |  Nagakura, Y., et al. 1999. Pharmacol Res. 39: 375-82. PMID: 10328995
  2. The structure and regulation of protein phosphatases.  |  Cohen, P. 1989. Annu Rev Biochem. 58: 453-508. PMID: 2549856
  3. Zacopride: anxiolytic profile in rodent and primate models of anxiety.  |  Costall, B., et al. 1988. J Pharm Pharmacol. 40: 302-5. PMID: 2900320
  4. Distribution and characterization of the [3H]granisetron-labelled 5-HT3 receptor in the human forebrain.  |  Bufton, KE., et al. 1993. Neuropharmacology. 32: 1325-31. PMID: 8152523
  5. Effects of 5-HT4-receptor agonists, cisapride, mosapride citrate, and zacopride, on cardiac action potentials in guinea pig isolated papillary muscles.  |  Kii, Y. and Ito, T. 1997. J Cardiovasc Pharmacol. 29: 670-5. PMID: 9213211

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Zacopride hydrochloride, 10 mg

sc-203723
10 mg
$137.00

Zacopride hydrochloride, 50 mg

sc-203723A
50 mg
$555.00