Z39Ig Antibody (6H8): sc-53977
- Z39Ig Antibody (6H8) is a mouse monoclonal IgG1 κ Z39Ig antibody, cited in 6 publications, provided at 200 µg/ml
- raised against Z39Ig-transfected HeLa cells of human origin
- Z39Ig Antibody (6H8) is recommended for detection of Z39Ig of human origin by WB, IP, IF and FCM
- Anti-Z39Ig Antibody (6H8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Z39Ig Antibody (6H8). This work is in progress.
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Z39Ig Antibody (6H8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Z39Ig protein of human origin by western blotting (WB), immunofluorescence (IF), and flow cytometry (FCM). Anti-Z39Ig antibody (6H8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Z39Ig is a member of the immunoglobulin superfamily of cell adhesion molecules (CAMs), which play a crucial role in mediating cell-cell and cell-matrix interactions. These interactions are vital for numerous biological processes, including cell growth, differentiation, and immune response, as well as in cancer metastasis. Z39Ig is primarily expressed in fetal human tissues, adult lungs, and placenta, highlighting its importance in developmental processes and tissue homeostasis. Z39Ig is localized in the pericentromeric region of human chromosome X, and Z39Ig expression is essential for proper embryonic morphogenic development and neuronal synaptic adhesion, which are critical for learning and memory. Dysregulation or mutation of CAM genes, including Z39Ig, has been implicated in various cancers, affecting tumor growth and metastasis, making Z39Ig a significant target for research in cancer biology and therapeutic interventions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Z39Ig Antibody (6H8) References:
- Cloning of Z39Ig, a novel gene with immunoglobulin-like domains located on human chromosome X. | Langnaese, K., et al. 2000. Biochim Biophys Acta. 1492: 522-5. PMID: 11004523
- Z39Ig is co-expressed with activated macrophage genes. | Walker, MG. 2002. Biochim Biophys Acta. 1574: 387-90. PMID: 11997108
- Identification of the genes differentially expressed in human dendritic cell subsets by cDNA subtraction and microarray analysis. | Ahn, JH., et al. 2002. Blood. 100: 1742-54. PMID: 12176896
- Characterization of monoclonal antibody specific to the Z39Ig protein, a member of immunoglobulin superfamily. | Kim, JK., et al. 2005. Immunol Lett. 99: 153-61. PMID: 16009265
- CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens. | Helmy, KY., et al. 2006. Cell. 124: 915-27. PMID: 16530040
- Z39Ig is expressed on macrophages and may mediate inflammatory reactions in arthritis and atherosclerosis. | Lee, MY., et al. 2006. J Leukoc Biol. 80: 922-8. PMID: 16882875
- To be or not to be B7. | Zang, X. and Allison, JP. 2006. J Clin Invest. 116: 2590-3. PMID: 17016555
- VSIG4, a B7 family-related protein, is a negative regulator of T cell activation. | Vogt, L., et al. 2006. J Clin Invest. 116: 2817-26. PMID: 17016562
- Structure of C3b in complex with CRIg gives insights into regulation of complement activation. | Wiesmann, C., et al. 2006. Nature. 444: 217-20. PMID: 17051150
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Z39Ig Antibody (6H8) | sc-53977 | 200 µg/ml | $316.00 | |||
Z39Ig Antibody (6H8): m-IgG Fc BP-HRP Bundle | sc-551777 | 200 µg Ab; 10 µg BP | $354.00 | |||
Z39Ig Antibody (6H8) AC | sc-53977 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Z39Ig Antibody (6H8) HRP | sc-53977 HRP | 200 µg/ml | $316.00 | |||
Z39Ig Antibody (6H8) FITC | sc-53977 FITC | 200 µg/ml | $330.00 | |||
Z39Ig Antibody (6H8) PE | sc-53977 PE | 200 µg/ml | $343.00 | |||
Z39Ig Antibody (6H8) Alexa Fluor® 488 | sc-53977 AF488 | 200 µg/ml | $357.00 | |||
Z39Ig Antibody (6H8) Alexa Fluor® 546 | sc-53977 AF546 | 200 µg/ml | $357.00 | |||
Z39Ig Antibody (6H8) Alexa Fluor® 594 | sc-53977 AF594 | 200 µg/ml | $357.00 | |||
Z39Ig Antibody (6H8) Alexa Fluor® 647 | sc-53977 AF647 | 200 µg/ml | $357.00 | |||
Z39Ig Antibody (6H8) Alexa Fluor® 680 | sc-53977 AF680 | 200 µg/ml | $357.00 | |||
Z39Ig Antibody (6H8) Alexa Fluor® 790 | sc-53977 AF790 | 200 µg/ml | $357.00 |