Z-VVR-AMC (CAS 124485-41-2)
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Alternate Names:
Cathepsin S & L substrate
CAS Number:
124485-41-2
Molecular Weight:
663.8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Z-VVR-AMC is a man-made peptide composed of the amino acids valine, arginine, and aminocaproic acid. It acts as an inhibitor of the enzyme human leukocyte elastase (HLE), which plays a central role in inflammatory processes. Z-VVR-AMC works by inhibiting HLE, a serine protease responsible for breaking down elastin, a critical part of the extracellular matrix. The inhibition of HLE by Z-VVR-AMC can potentially impede the degradation of elastin, thereby possibly reducing inflammation and improving airway function.
Z-VVR-AMC (CAS 124485-41-2) References
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- Aggregate formation in the spinal cord of mutant SOD1 transgenic mice is reversible and mediated by proteasomes. | Puttaparthi, K., et al. 2003. J Neurochem. 87: 851-60. PMID: 14622116
- Characterization of amino acid variation at strategic positions in parasite and human proteases for selective inhibition of falcipains in Plasmodium falciparum. | Goh, LL. and Sim, TS. 2005. Biochem Biophys Res Commun. 335: 762-70. PMID: 16095562
- Non-neuronal induction of immunoproteasome subunits in an ALS model: possible mediation by cytokines. | Puttaparthi, K. and Elliott, JL. 2005. Exp Neurol. 196: 441-51. PMID: 16242125
- Assessing the role of immuno-proteasomes in a mouse model of familial ALS. | Puttaparthi, K., et al. 2007. Exp Neurol. 206: 53-8. PMID: 17482163
- Conformational flexibility and allosteric regulation of cathepsin K. | Novinec, M., et al. 2010. Biochem J. 429: 379-89. PMID: 20450492
- Cloning, expression analysis and enzymatic characterization of cathepsin S from olive flounder (Paralichthys olivaceus). | Kim, NY., et al. 2010. Comp Biochem Physiol B Biochem Mol Biol. 157: 238-47. PMID: 20601061
- Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis. | Porter, K., et al. 2013. Autophagy. 9: 581-94. PMID: 23360789
- A simple methodology to assess endolysosomal protease activity involved in antigen processing in human primary cells. | Vaithilingam, A., et al. 2013. BMC Cell Biol. 14: 35. PMID: 23937268
- Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. | Xu, P., et al. 2014. J Ocul Pharmacol Ther. 30: 246-53. PMID: 24552277
- The application of a novel, cell permeable activity-based probe for the detection of cysteine cathepsins. | Hughes, CS., et al. 2016. Biochem Biophys Res Commun. 472: 444-50. PMID: 26792724
- Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages. | Hughes, CS., et al. 2016. Part Fibre Toxicol. 13: 19. PMID: 27108091
- Regulation of extrinsic pathway factor Xa formation by tissue factor pathway inhibitor. | Baugh, RJ., et al. 1998. J Biol Chem. 273: 4378-86. PMID: 9468488
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Z-VVR-AMC, 10 mg | sc-471150 | 10 mg | $136.00 |