Date published: 2026-4-4

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Z-Phe-Phe-OH (CAS 13122-91-3)

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Alternate Names:
N-Carbobenzoxy-L-phenylalanyl-L-phenylalanine; Z-L-phenylalanyl-L-phenylalanine
CAS Number:
13122-91-3
Molecular Weight:
446.5
Molecular Formula:
C26H26N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Z-Phe-Phe-OH is a dipeptide compound that functions as an inhibitor in enzymatic reactions. It acts by binding to the active site of specific enzymes, preventing their normal substrate from binding and inhibiting their catalytic activity. Z-Phe-Phe-Oh is known to interact with proteases and peptidases, disrupting their function and leading to the inhibition of peptide bond cleavage. Z-Phe-Phe-OH achieves this by forming stable complexes with the active site of the enzyme, thereby interfering with the normal enzymatic process. Its mechanism of action involves specific interactions with amino acid residues within the enzyme′s active site, disrupting the catalytic mechanism and leading to the inhibition of enzymatic activity. Z-Phe-Phe-Oh′s ability to inhibit specific enzymes may be useful for studying enzyme function and developing a deeper understanding of their role in biological processes.


Z-Phe-Phe-OH (CAS 13122-91-3) References

  1. α-N-Protected dipeptide acids: a simple and efficient synthesis via the easily accessible mixed anhydride method using free amino acids in DMSO and tetrabutylammonium hydroxide.  |  Verardo, G. and Gorassini, A. 2013. J Pept Sci. 19: 315-24. PMID: 23495228
  2. Synthetic Receptors Based on Abiotic Cyclo(pseudo)peptides.  |  Kubik, S. 2022. Molecules. 27: PMID: 35566168
  3. Proteinase-catalyzed synthesis of peptide bonds.  |  Fruton, JS. 1982. Adv Enzymol Relat Areas Mol Biol. 53: 239-306. PMID: 7036680
  4. Effects of normal and their branched alcohols with structurally minimal variation on kinetic parameters in thermolysin-catalyzed peptide hydrolysis and synthesis of N-(benzyloxycarbonyl)-L-phenylalanyl-L-phenylalanine and its methyl ester.  |  Inagaki, T., et al. 1995. Biosci Biotechnol Biochem. 59: 535-7. PMID: 7766199
  5. Pepsin-catalyzed peptide synthesis in organic media: studies with free and immobilized enzyme.  |  Bemquerer, MP., et al. 1994. Int J Pept Protein Res. 44: 448-56. PMID: 7896503

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Z-Phe-Phe-OH, 1 g

sc-471013
1 g
$53.00