Date published: 2026-2-13

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(Z-LL)2 Ketone (CAS 313664-40-3)

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Alternate Names:
1,3-di-(N-Carboxybenzoyl-L-leucyl-L-leucyl)amino Acetone
Application:
(Z-LL)2 Ketone is a novel cysteine protease inhibitor
CAS Number:
313664-40-3
Molecular Weight:
809.00
Molecular Formula:
C43H64N6O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(Z-LL)2 Ketone is a synthetic peptide aldehyde used as a proteasome inhibitor in biochemical research. Its primary application is to inhibit the chymotrypsin-like activity of the proteasome, which is a protein complex responsible for degrading ubiquitinated proteins. The inhibition of proteasomal activity by (Z-LL)2 Ketone allows researchers to study the regulation of protein turnover, the cellular response to misfolded or damaged proteins, and the role of the ubiquitin-proteasome system in controlling various cellular processes. Moreover, this compound is instrumental in elucidating the mechanisms of action of the proteasome in cell cycle regulation, gene expression, and signal transduction. (Z-LL)2 Ketone is also used to investigate the consequences of proteasome inhibition in various disease models, particularly those related to protein aggregation and proteostasis.


(Z-LL)2 Ketone (CAS 313664-40-3) References

  1. Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor.  |  Weihofen, A., et al. 2000. J Biol Chem. 275: 30951-6. PMID: 10921927
  2. Identification of signal peptide peptidase, a presenilin-type aspartic protease.  |  Weihofen, A., et al. 2002. Science. 296: 2215-8. PMID: 12077416
  3. Analysis of polypeptides by sodium dodecyl sulfate-polyacrylamide gel electrophoresis alongside in vitro-generated reference peptides.  |  Lemberg, MK. and Martoglio, B. 2003. Anal Biochem. 319: 327-31. PMID: 12871730
  4. A misassembled transmembrane domain of a polytopic protein associates with signal peptide peptidase.  |  Crawshaw, SG., et al. 2004. Biochem J. 384: 9-17. PMID: 15373738
  5. Core protein of pestiviruses is processed at the C terminus by signal peptide peptidase.  |  Heimann, M., et al. 2006. J Virol. 80: 1915-21. PMID: 16439547
  6. Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals.  |  Dev, KK., et al. 2006. Eur J Pharmacol. 540: 10-7. PMID: 16697367
  7. Expression of TNF-alpha leader sequence renders MCF-7 tumor cells resistant to the cytotoxicity of soluble TNF-alpha.  |  Yan, D., et al. 2009. Breast Cancer Res Treat. 116: 91-102. PMID: 18618239
  8. Plasmodium falciparum signal peptide peptidase is a promising drug target against blood stage malaria.  |  Li, X., et al. 2009. Biochem Biophys Res Commun. 380: 454-9. PMID: 19174148
  9. Characterization of hepatitis C virus core protein multimerization and membrane envelopment: revelation of a cascade of core-membrane interactions.  |  Ai, LS., et al. 2009. J Virol. 83: 9923-39. PMID: 19605478
  10. Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana.  |  Hoshi, M., et al. 2013. BMC Biochem. 14: 16. PMID: 23829174
  11. Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo.  |  Allen, SJ., et al. 2014. Exp Eye Res. 123: 8-15. PMID: 24768597
  12. Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors.  |  Ran, Y., et al. 2015. PLoS One. 10: e0128619. PMID: 26046535
  13. Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis.  |  Mentrup, T., et al. 2019. J Exp Med. 216: 807-830. PMID: 30819724

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(Z-LL)2 Ketone, 5 mg

sc-311559
5 mg
$250.00