Molecular structure of Z-L-Abu-CONH(CH2)3-morpholine, CAS Number: 145731-49-3
Z-L-Abu-CONH(CH2)3-morpholine (CAS 145731-49-3)
Alternate Names:
Calpain Inhibitor XI
Application:
Z-L-Abu-CONH(CH2)3-morpholine is a selective, reversible inhibitor of calpain-1 and calpain-2
CAS Number:
145731-49-3
Molecular Weight:
504.62
Molecular Formula:
C26H40N4O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Z-L-Abu-CONH(CH2)3-morpholine is a cell-permeable dipeptidyl alpha-ketoamide that acts as a potent, highly selective, reversible, and active site inhibitor of Calpain 1 and Calpain 2 (Ki = 140 nM and 41 nM, respectively). A weak inhibitor of cathepsin B (Ki = 6.9 muM). May have a neuroprotective role in the central nervous system following focal ischemia. Also protects against virus-induced apoptotic myocardial injury in mice.
Z-L-Abu-CONH(CH2)3-morpholine (CAS 145731-49-3) References
- Calpain is activated in degenerating photoreceptors in the rd1 mouse. | Paquet-Durand, F., et al. 2006. J Neurochem. 96: 802-14. PMID: 16405498
- Calpain inhibitors delay injury-induced apoptosis in adult mouse spinal cord motor neurons. | Momeni, HR. and Kanje, M. 2006. Neuroreport. 17: 761-5. PMID: 16708011
- Downregulation of NF-kappaB signaling by mutant huntingtin proteins induces oxidative stress and cell death. | Reijonen, S., et al. 2010. Cell Mol Life Sci. 67: 1929-41. PMID: 20232225
- Photoreceptor rescue and toxicity induced by different calpain inhibitors. | Paquet-Durand, F., et al. 2010. J Neurochem. 115: 930-40. PMID: 20807308
- TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts. | Connor, AM., et al. 2012. Arthritis Res Ther. 14: R62. PMID: 22417670
- Calpain inhibitor nanocrystals prepared using Nano Spray Dryer B-90. | Baba, K. and Nishida, K. 2012. Nanoscale Res Lett. 7: 436. PMID: 22863139
- Calpain inhibitor and ibudilast rescue β cell functions in a cellular model of Wolfram syndrome. | Nguyen, LD., et al. 2020. Proc Natl Acad Sci U S A. 117: 17389-17398. PMID: 32632005
- Wolfram Syndrome: a Monogenic Model to Study Diabetes Mellitus and Neurodegeneration. | Fischer, TT. and Ehrlich, BE. 2020. Curr Opin Physiol. 17: 115-123. PMID: 32864536
- Elevated MCU Expression by CaMKIIδB Limits Pathological Cardiac Remodeling. | Wang, P., et al. 2022. Circulation. 145: 1067-1083. PMID: 35167328
- Histone 2B Facilitates Plasminogen-Enhanced Endothelial Migration through Protease-Activated Receptor 1 (PAR1) and Protease-Activated Receptor 2 (PAR2). | Das, M., et al. 2022. Biomolecules. 12: PMID: 35204713
Inhibitor of:
Calpain 1, Calpain 2, and cathepsin B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Z-L-Abu-CONH(CH2)3-morpholine, 1 mg | sc-301996 | 1 mg | $148.00 | |||
Z-L-Abu-CONH(CH2)3-morpholine, 5 mg | sc-301996A | 5 mg | $408.00 |