Date published: 2025-10-31

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Z-Gly-Pro-OH (CAS 1160-54-9)

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Alternate Names:
Z-L-glycyl-L-proline
CAS Number:
1160-54-9
Molecular Weight:
306.32
Molecular Formula:
C15H18N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Z-Gly-Pro-OH is a cyclic dipeptide, comprising two amino acids linked by a peptide bond. It plays a vital role in numerous processes, drawing significant attention in scientific research. The scientific research applications of Z-Gly-Pro-OH have been diverse and impactful. Researchers have utilized it extensively to delve into the structures and functions of proteins, peptides, and enzymes. Moreover, it has been a valuable asset in the study of cell membranes and signaling pathways, unraveling key insights into cellular processes. Additionally, Z-Gly-Pro-OH′s contribution to the understanding of DNA, RNA, and metabolic pathways cannot be overlooked. Regarding its mechanism of action, some uncertainties remain. Yet, it is postulated that the cyclic dipeptide binds to specific proteins and peptides, thereby triggering a cascade of interactions that regulate vital cellular processes. For instance, it has been observed to bind to certain enzymes, facilitating the catalysis of new molecule formation or the breakdown of existing molecules.


Z-Gly-Pro-OH (CAS 1160-54-9) References

  1. The noncatalytic beta-propeller domain of prolyl oligopeptidase enhances the catalytic capability of the peptidase domain.  |  Szeltner, Z., et al. 2000. J Biol Chem. 275: 15000-5. PMID: 10747969
  2. Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase.  |  Szeltner, Z., et al. 2002. J Biol Chem. 277: 44597-605. PMID: 12228249
  3. Characterisation of the active site of a newly-discovered and potentially significant post-proline cleaving endopeptidase called ZIP using LC-UV-MS.  |  McMahon, G., et al. 2003. Analyst. 128: 670-5. PMID: 12866886
  4. Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.  |  Alonso De Diego, SA., et al. 2005. Bioorg Med Chem Lett. 15: 2279-83. PMID: 15837309
  5. Properties of the prolyl oligopeptidase homologue from Pyrococcus furiosus.  |  Juhász, T., et al. 2006. FEBS Lett. 580: 3493-7. PMID: 16714022
  6. Ligand-induced conformational changes in prolyl oligopeptidase: a kinetic approach.  |  Van Elzen, R., et al. 2017. Protein Eng Des Sel. 30: 217-224. PMID: 28062644
  7. Room temperature decarboxylative cyanation of carboxylic acids using photoredox catalysis and cyanobenziodoxolones: a divergent mechanism compared to alkynylation.  |  Le Vaillant, F., et al. 2017. Chem Sci. 8: 1790-1800. PMID: 28451301
  8. Clostridium histolyticum collagenase: development of new thio ester, fluorogenic, and depsipeptide substrates and new inhibitors.  |  Vencill, CF., et al. 1985. Biochemistry. 24: 3149-57. PMID: 2992578
  9. Photochemical Strain-Release-Driven Cyclobutylation of C(sp3)-Centered Radicals.  |  Ernouf, G., et al. 2020. Angew Chem Int Ed Engl. 59: 2618-2622. PMID: 31599038
  10. Studies of substrate requirements, kinetic properties, and competive inhibitors of the enzymes catabolizing TRH in rat brain.  |  Busby, WH., et al. 1982. Brain Res. 242: 261-70. PMID: 6126250
  11. NMR studies of a free and protected tetrapeptide glycyl-L-prolylglycylglycine in beta-turn-supporting environment.  |  Perly, B., et al. 1983. Biopolymers. 22: 1853-68. PMID: 6616010

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Z-Gly-Pro-OH, 1 g

sc-296758
1 g
$70.00

Z-Gly-Pro-OH, 5 g

sc-296758A
5 g
$206.00