Z-DEVD-pNA
Alternate Names:
Caspase-3 substrate (chromogenic)
Application:
Z-DEVD-pNA is a caspase-3 chromogenic substrate with increased cell permeability
Purity:
≥99%
Molecular Weight:
730.7
Molecular Formula:
C32H38N6O14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Z-DEVD-pNA is a caspase-3 chromogenic substrate with increased cell permeability. It is also a substrate for caspase-1,caspase-4 and caspase-7. λmax of pNA is 400nm. Z-DEVD-pNA is similar to Ac-DEVD-pNA except the N-terminus is blocked by a benzyloxycarbonyl (Z) moiety which may increase cell permeability.
Z-DEVD-pNA References
- Bcl-xL does not inhibit the function of Apaf-1. | Newmeyer, DD., et al. 2000. Cell Death Differ. 7: 402-7. PMID: 10773825
- 2-Methoxyestradiol-induced caspase-3 activation and apoptosis occurs through G(2)/M arrest dependent and independent pathways in gastric carcinoma cells. | Lin, HL., et al. 2001. Cancer. 92: 500-9. PMID: 11505393
- Nitric oxide protects human extravillous trophoblast cells from apoptosis by a cyclic GMP-dependent mechanism and independently of caspase 3 nitrosylation. | Dash, PR., et al. 2003. Exp Cell Res. 287: 314-24. PMID: 12837287
- I1 imidazoline receptor-mediated effects on apoptotic processes in PC12 cells. | Dupuy, L., et al. 2004. Cell Death Differ. 11: 1049-52. PMID: 15143350
- Trophoblast apoptosis is inhibited by hepatocyte growth factor through the Akt and beta-catenin mediated up-regulation of inducible nitric oxide synthase. | Dash, PR., et al. 2005. Cell Signal. 17: 571-80. PMID: 15683732
- Protective effects of cyanidin-3-O-beta-glucopyranoside against UVA-induced oxidative stress in human keratinocytes. | Tarozzi, A., et al. 2005. Photochem Photobiol. 81: 623-9. PMID: 15701043
- Saucernetin-7 isolated from Saururus chinensis induces caspase-dependent apoptosis in human promyelocytic leukemia HL-60 cells. | Choi, SK., et al. 2007. Biol Pharm Bull. 30: 1516-22. PMID: 17666813
- Ginsenoside Rh2 induces ligand-independent Fas activation via lipid raft disruption. | Yi, JS., et al. 2009. Biochem Biophys Res Commun. 385: 154-9. PMID: 19445898
- Caspase dependence of the death of neonatal retinal ganglion cells induced by axon damage and induction of autophagy as a survival mechanism. | Sternberg, C., et al. 2010. Braz J Med Biol Res. 43: 950-6. PMID: 20802972
- A novel hydroxamic acid derivative, MHY218, induces apoptosis and cell cycle arrest through downregulation of NF-κB in HCT116 human colon cancer cells. | Kim, MK., et al. 2014. Int J Oncol. 44: 256-64. PMID: 24190633
- Livin modulates the apoptotic effects of vesicular stomatotitis virus in lung adenocarcinoma. | Liu, GH., et al. 2015. Int J Oncol. 47: 1775-82. PMID: 26412467
- Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. | Nicholson, DW., et al. 1995. Nature. 376: 37-43. PMID: 7596430
- Interleukin-1 beta converting enzyme. | Thornberry, NA. 1994. Methods Enzymol. 244: 615-31. PMID: 7845238
- Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. | Lazebnik, YA., et al. 1994. Nature. 371: 346-7. PMID: 8090205
- Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis. | Datta, R., et al. 1997. J Biol Chem. 272: 1965-9. PMID: 8999887
Substrate of:
caspase-1, caspase-3, caspase-4, and caspase-7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Z-DEVD-pNA, 1 mg | sc-296747 | 1 mg | $51.00 | |||
Z-DEVD-pNA, 5 mg | sc-296747A | 5 mg | $77.00 |