Molecular structure of Z-DEVD-FMK, CAS Number: 210344-95-9
Z-DEVD-FMK (CAS 210344-95-9)
See product citations (58)
Alternate Names:
Z-DEVD-FMK is also known as Caspase-3 Inhibitor.
Application:
Z-DEVD-FMK is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10
CAS Number:
210344-95-9
Purity:
≥98%
Molecular Weight:
668.66
Molecular Formula:
C30H41N4O12F
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Z-DEVD-FMK also known as Caspase-3 Inhibitor is a cell-permeable, potent, and irreversible inhibitor of caspase-3, caspase-6, caspase-7, caspase-8 and caspase-10. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Following use of the inhibitor, standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.For the fluorometric determination of caspase-3 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-3 Kit (sc-4263 AK).
Z-DEVD-FMK (CAS 210344-95-9) References
- Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. | Henshall, DC., et al. 2000. J Neurochem. 74: 1215-23. PMID: 10693954
- Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway. | Kugawa, F., et al. 2000. Biol Pharm Bull. 23: 930-5. PMID: 10963298
- The neuroprotective effects of z-DEVD.fmk, a caspase-3 inhibitor, on traumatic spinal cord injury in rats. | Barut, S., et al. 2005. Surg Neurol. 64: 213-20; discussion 220. PMID: 16099247
- Central administration of a caspase inhibitor impairs shuttle-box performance in rats. | Stepanichev, MY., et al. 2005. Neuroscience. 136: 579-91. PMID: 16198488
- [Effects of intracerebroventricular administration of a caspase-3 inhibitor Z-DEVD-FMK on behavior of rats]. | Stapanichev, MIu., et al. 2006. Zh Vyssh Nerv Deiat Im I P Pavlova. 56: 247-56. PMID: 16756133
- [Experimental study on treatment of rabbits optic nerve injury with Caspase-3 inhibitor z-DEVD-fmk]. | Zhang, W., et al. 2010. Zhonghua Yan Ke Za Zhi. 46: 1084-9. PMID: 21211221
- The caspase-3 inhibitor (peptide Z-DEVD-FMK) affects the survival and function of platelets in platelet concentrate during storage. | Shiri, R., et al. 2014. Blood Res. 49: 49-53. PMID: 24724067
- Caspase-3 inhibitor Z-DEVD-FMK enhances retinal ganglion cell survival and vision restoration after rabbit traumatic optic nerve injury. | Liu, Y., et al. 2015. Restor Neurol Neurosci. 33: 205-20. PMID: 25588462
- Involvement of caspase-3/PTEN signaling pathway in isoflurane-induced decrease of self-renewal capacity of hippocampal neural precursor cells. | Chen, X., et al. 2015. Brain Res. 1625: 275-86. PMID: 26367448
- Biochemical characterization of unusual cysteine protease of P. falciparum, metacaspase-2 (MCA-2). | Vandana, ., et al. 2018. Mol Biochem Parasitol. 220: 28-41. PMID: 29317266
- Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure. | Xu, WF., et al. 2021. Acta Pharmacol Sin. 42: 68-76. PMID: 32457417
- Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy. | Li, W., et al. 2021. Front Pharmacol. 12: 780790. PMID: 34867412
- Osthole Induces Apoptosis and Caspase-3/GSDME-Dependent Pyroptosis via NQO1-Mediated ROS Generation in HeLa Cells. | Wang, J., et al. 2022. Oxid Med Cell Longev. 2022: 8585598. PMID: 35720178
- Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3. | Brockstedt, E., et al. 1998. J Biol Chem. 273: 28057-64. PMID: 9774422
Inhibitor of:
Apoptosis, caspase-10, caspase-3, caspase-6, caspase-7, caspase-8, and Chemical and Peptide Caspase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Z-DEVD-FMK, 1 mg | sc-311558 | 1 mg | $243.00 | |||
Z-DEVD-FMK, 5 mg | sc-311558A | 5 mg | $999.00 |