(Z-Asp-Glu-Val-Asp)2-Rh110, also known as Caspase 3 (Apopain) Substrate 1r-z is a fluorogenic substrate for caspase 3. Rh110 (Rhodamine 110)-derived caspase substrates are probably the most sensitive indicators widely used for the fluorimetric detection of various caspase activities.
Cleavage of Rh110 peptides by caspases generates strongly fluorescent Rh110 that can be monitored fluorimetrically at 510-530 nm with excitation of 488 nm, the most common excitation light source used in fluorescence instruments.
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See how others have used (Z-Asp-Glu-Val-Asp)2-Rh110 (CAS 220846-75-3). Click on the entry to view the PubMed entry .
PMID: # 28820959 Totzke, J. et al. 2017. Cell Chem Biol. 24: 1029-1039.e7.
PMID: # 27265747 Alwarawrah, Y. et al. 2016. Cell Chem Biol. 23: 678-88.
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