Molecular structure of Z-Asp-2,6-dichlorobenzoyloxymethylketone, CAS Number: 153088-73-4
Z-Asp-2,6-dichlorobenzoyloxymethylketone (CAS 153088-73-4)
Alternate Names:
Caspase-1 Inhibitor V
Application:
Z-Asp-2,6-dichlorobenzoyloxymethylketone is a broad Caspase Inhibitor
CAS Number:
153088-73-4
Purity:
>98%
Molecular Weight:
454.3
Molecular Formula:
C20H17Cl2NO7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Z-Asp-2,6-dichlorobenzoyloxymethylketone (Z-Asp-CH2-DCB), a cell permeable broad Caspase Inhibitor, prevents development of severe pulmonary hypertension and intravascular pulmonary endothelial cell growth caused by chronic hypoxia in murine models. This compound has also been shown to prevent des-ring B colchicine induced apoptosis of cells. Evaluation of Z-Asp-CH2-DCB on caspase inhibition has shown a reduced rate of cleavage of Troponin I-C, an important component of cardiac contractile apparatus. Z-Asp-2,6-dichlorobenzoyloxymethylketone is an inhibitor of caspase-3 and caspase-6.
Z-Asp-2,6-dichlorobenzoyloxymethylketone (CAS 153088-73-4) References
- Role of caspases in hypoxia-induced necrosis of rat renal proximal tubules. | Edelstein, CL., et al. 1999. J Am Soc Nephrol. 10: 1940-9. PMID: 10477146
- Involvement of mitochondria and caspase-3 in ET-18-OCH(3)-induced apoptosis of human leukemic cells. | Gajate, C., et al. 2000. Int J Cancer. 86: 208-18. PMID: 10738248
- Expression of genes involved in initiation, regulation, and execution of apoptosis in human neutrophils and during neutrophil differentiation of HL-60 cells. | Santos-Beneit, AM. and Mollinedo, F. 2000. J Leukoc Biol. 67: 712-24. PMID: 10811013
- Induction of apoptosis in leukemic cells by the reversible microtubule-disrupting agent 2-methoxy-5-(2',3',4'-trimethoxyphenyl)-2,4,6-cycloheptatrien-1 -one: protection by Bcl-2 and Bcl-X(L) and cell cycle arrest. | Gajate, C., et al. 2000. Cancer Res. 60: 2651-9. PMID: 10825137
- Downregulation of the calpain inhibitor protein calpastatin by caspases during renal ischemia-reperfusion. | Shi, Y., et al. 2000. Am J Physiol Renal Physiol. 279: F509-17. PMID: 10966930
- Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. | Taraseviciene-Stewart, L., et al. 2001. FASEB J. 15: 427-38. PMID: 11156958
- Caspase-independent apoptosis induced by differentiation-inducing factor of Dicytostelium discoideum in INS-1 cells. | Fujimaki, S., et al. 2001. Eur J Pharmacol. 421: 93-100. PMID: 11399264
- A bradykinin antagonist and a caspase inhibitor prevent severe pulmonary hypertension in a rat model. | Taraseviciene-Stewart, L., et al. 2002. Can J Physiol Pharmacol. 80: 269-74. PMID: 12025960
- Long-term caspase inhibition ameliorates apoptosis, reduces myocardial troponin-I cleavage, protects left ventricular function, and attenuates remodeling in rats with myocardial infarction. | Chandrashekhar, Y., et al. 2004. J Am Coll Cardiol. 43: 295-301. PMID: 14736452
- Apoptosis is caused by prolonged organ preservation and blocked by apoptosis inhibitor in experimental rat pancreatic grafts. | Liu, X., et al. 2004. Transplant Proc. 36: 1209-10. PMID: 15194419
- Effects of organ preservation, ischemia time and caspase inhibition on apoptosis and microcirculation in rat pancreas transplantation. | Drognitz, O., et al. 2004. Am J Transplant. 4: 1042-50. PMID: 15196060
- Caspase-Independent Apoptosis Induced by Reperfusion Following Ischemia without Bile Duct Occlusion in Rat Liver. | Matsui, N., et al. 2017. Biol Pharm Bull. 40: 104-107. PMID: 28049941
- Fas-mediated apoptosis in mouse hepatocytes involves the processing and activation of caspases. | Jones, RA., et al. 1998. Hepatology. 27: 1632-42. PMID: 9620337
Inhibitor of:
Apoptosis, caspase-3, caspase-6, and Chemical and Peptide Caspase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Z-Asp-2,6-dichlorobenzoyloxymethylketone, 10 mg | sc-202386 | 10 mg | $93.00 | |||
Z-Asp-2,6-dichlorobenzoyloxymethylketone, 50 mg | sc-202386A | 50 mg | $402.00 |