Molecular structure of YS121, CAS Number: 916482-17-2
YS121 (CAS 916482-17-2)
Application:
YS121 is an inhibitor of mPGES-1, 5-LO, Cox-1, and Cox-2
CAS Number:
916482-17-2
Molecular Weight:
408.0
Molecular Formula:
C20H26ClN3O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
YS121 is a dual inhibitor of mPGES-1 (IC50 = 3.9 μM) and 5-LO (IC50 = 4.1 μM). It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. Moreover, YS121 (1.5 mg/kg, intraperitoneal) reduced pleural levels of PGE2 and LTB4 while blocking exudate formation and leukocyte infiltration in carrageenan-induced rat pleurisy. YS121 has minor effects on Cox-1 and Cox-2, inhibiting these enzymes 24.8% and 38%, respectively, at 10 μM.
YS121 (CAS 916482-17-2) References
- Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid. | Werz, O., et al. 2008. J Med Chem. 51: 5449-53. PMID: 18710209
- Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. | Koeberle, A., et al. 2008. J Med Chem. 51: 8068-76. PMID: 19053751
- The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. | Koeberle, A., et al. 2010. J Pharmacol Exp Ther. 332: 840-8. PMID: 19934399
- Tertiary alkylamines as nucleophiles in substitution reactions at heteroaromatic halide during the synthesis of the highly potent pirinixic acid derivative 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS-121). | Gabler, M. and Schubert-Zsilavecz, M. 2011. Molecules. 16: 10013-28. PMID: 22143571
- Loss of natural killer T cells promotes pancreatic cancer in LSL-KrasG12D/+ mice. | Janakiram, NB., et al. 2017. Immunology. 152: 36-51. PMID: 28419443
Inhibitor of:
5-LO, Cox-2, and TEF-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
YS121, 1 mg | sc-296707 | 1 mg | $56.00 | |||
YS121, 5 mg | sc-296707A | 5 mg | $251.00 |