Molecular structure of Yohimbine hydrochloride, CAS Number: 65-19-0
Yohimbine hydrochloride (CAS 65-19-0)
See product citations (2)
Alternate Names:
Rauwolscine hydrochloride
Application:
Yohimbine hydrochloride is an α2-adrenoceptor antagonist
CAS Number:
65-19-0
Purity:
≥98%
Molecular Weight:
390.91
Molecular Formula:
C21H26N2O3•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Yohimbine hydrochloride is a compound that functions as an alpha-2 adrenergic receptor antagonist. It acts by blocking the pre-synaptic alpha-2 adrenergic receptors, leading to an increase in the release of norepinephrine. At the molecular level, yohimbine hydrochloride competes with norepinephrine for binding to the alpha-2 adrenergic receptors, preventing the negative feedback inhibition of norepinephrine release. This mechanism of action ultimately leads to an increase in sympathetic outflow and can have effects on various physiological processes. In a research and development setting, yohimbine hydrochloride′s mechanism of action can be utilized to investigate the role of the sympathetic nervous system in different biological processes and to study the effects of increased sympathetic activity on specific physiological functions.
Yohimbine hydrochloride (CAS 65-19-0) References
- Anesthesia induced by administration of xylazine hydrochloride alone or in combination with ketamine hydrochloride and reversal by administration of yohimbine hydrochloride in captive Axis deer (Axis axis). | Sontakke, SD., et al. 2007. Am J Vet Res. 68: 20-4. PMID: 17199414
- Platelet responsiveness to yohimbine hydrochloride and MRS2179 in the context of the interaction between collagen and epinephrine in acute coronary syndrome. | Lahiri, P., et al. 2009. Blood Cells Mol Dis. 43: 105-10. PMID: 19272818
- Yohimbine bioavailability in humans. | Guthrie, SK., et al. 1990. Eur J Clin Pharmacol. 39: 409-11. PMID: 2076728
- Yohimbine hydrochloride ameliorates collagen type-II-induced arthritis targeting oxidative stress and inflammatory cytokines in Wistar rats. | Neha, ., et al. 2017. Environ Toxicol. 32: 619-629. PMID: 27028940
- Antagonism of xylazine hydrochloride with yohimbine hydrochloride and 4-aminopyridine in captive wapiti. | Renecker, LA. and Olsen, CD. 1986. J Wildl Dis. 22: 91-6. PMID: 3005668
- The impact of Yohimbine-induced arousal on facets of behavioural impulsivity. | Herman, AM., et al. 2019. Psychopharmacology (Berl). 236: 1783-1795. PMID: 30635680
- Yohimbine hydrochloride inhibits benign prostatic hyperplasia by downregulating steroid 5α-reductase type 2. | Zhao, Y., et al. 2021. Eur J Pharmacol. 908: 174334. PMID: 34265299
- Immobilization of coyotes with xylazine hydrochloride-ketamine hydrochloride and antagonism by yohimbine hydrochloride. | Kreeger, TJ. and Seal, US. 1986. J Wildl Dis. 22: 604-6. PMID: 3503155
- Yohimbine hydrochloride inhibits skin melanin synthesis by regulating wnt/β-catenin and p38/MAPK signal pathways. | Fu, T., et al. 2022. J Dermatol Sci. 107: 17-23. PMID: 35840473
- Yohimbine hydrochloride reversal of ketamine hydrochloride and xylazine hydrochloride immobilization of Bengal tigers and effects on hematology and serum chemistries. | Seal, US., et al. 1987. J Wildl Dis. 23: 296-300. PMID: 3586208
- Effect of caffeine sodium benzoate, ketamine hydrochloride, and yohimbine hydrochloride on xylazine hydrochloride-induced anorexia in white-tailed deer. | Van der Eems, K. and Brown, RD. 1986. J Wildl Dis. 22: 403-6. PMID: 3735587
- Use of yohimbine hydrochloride to reverse immobilization of polar bears by ketamine hydrochloride and xylazine hydrochloride. | Ramsay, MA., et al. 1985. J Wildl Dis. 21: 396-400. PMID: 4078975
- Yohimbine hydrochloride as an antagonist to xylazine hydrochloride-ketamine hydrochloride immobilization of white-tailed deer. | Mech, LD., et al. 1985. J Wildl Dis. 21: 405-10. PMID: 4078977
Inhibitor of:
α2A-AR, α2B-AR, alpha1A-AR, alpha2A-AR, alpha2B-AR, alpha2C-AR, Dexras2, Gα z, GPR158, Gpr165, GPR171, INMT, MrgB5, NPFF, Olfr1, Olfr10, Olfr1000, Olfr1012, Olfr1013, Olfr1018, Olfr1019, Olfr1022, Olfr1023, Olfr1030, Olfr1032, Olfr1034, Olfr1039, Olfr1049, Olfr1087, Olfr1100, Olfr1109, Olfr151, Olfr224, Olfr265, Olfr341, Olfr392, Olfr584, Olfr668, Olfr669, Olfr67, Olfr670, Olfr671, Olfr672, Olfr675, Olfr676, Olfr677, Olfr678, Olfr679, Olfr68, Olfr681, Olfr683, Olfr684, Olfr685, Olfr686, Olfr688, Olfr689, Olfr69, Olfr690, Olfr735, Olfr736, Olfr738, Olfr765, Olfr767, Olfr768, Olfr772, Olfr829, Olfr881, Olfr94, Olr1076, Olr1096, Olr1104, Olr1228, Olr1425, Olr1431, Olr1433, Olr1462, Olr1488, Olr1519, Olr1520, Olr1545, Olr1546, Olr1547, Olr1559, Olr1567, Olr1569, Olr1593, Olr1602, Olr1639, Olr1640, Olr1664, Olr226, Olr23, Olr25, Olr257, Olr3, Olr336, Olr358, Olr404, Olr552, Olr657, Olr709, Olr713, Olr747, Olr792, Olr804, Olr840, Olr905, OR2M, OR3A1, TAAR7H, TAAR8C, TRH-DE, TRH-R2, V1RB7, V1rc3132, V1RI2, Vmn1r123, Vmn1r139, Vmn1r15, Vmn1r152, Vmn1r163, Vmn1r17, Vmn1r184, Vmn1r196, Vmn1r30, Vmn1r34, Vmn1r61, Vmn1r86, Vmn1r88, Vmn2r100, Vmn2r24, Vmn2r25, Vmn2r32, Vmn2r35, Vmn2r45, Vmn2r48, Vmn2r51, Vmn2r55, Vmn2r59, Vmn2r6, Vmn2r68, Vmn2r76, Vmn2r77, Vmn2r81, Vmn2r83, and Vmn2r93.Activator of:
α1B-AR, β-Arrestin-1, COPE, ET-3, GPR115, GPR26, MC4-R, Neuropeptide S, NMUR2, Olr22, Rim2, T2R60, Vmn1r-ps4, Vmn1r125, and Vmn2r31.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Yohimbine hydrochloride, 1 g | sc-204412 | 1 g | $50.00 | |||
Yohimbine hydrochloride, 5 g | sc-204412A | 5 g | $168.00 | |||
Yohimbine hydrochloride, 25 g | sc-204412B | 25 g | $520.00 |