Molecular structure of YM 976, CAS Number: 191219-80-4
YM 976 (CAS 191219-80-4)
Alternate Names:
4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one
Application:
YM 976 is an inhibitor of PDE4
CAS Number:
191219-80-4
Purity:
≥98%
Molecular Weight:
313.79
Molecular Formula:
C17H16ClN3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Orally active inhibits PDE4 (IC50 = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration.
YM 976 (CAS 191219-80-4) References
Aoki et al (2000) A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity. J.Pharmacol.Exp.Ther. 295 255. Aoki et al (2001) Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. J.Pharmacol.Exp.Ther. 298 1142. Moriuchi et al (2003) Relaxant effect of YM976, a novel phosphodiesterase 4 inhibitor, on bovine tracheal smooth muscle. Eur.J.Pharmacol. 470 57.Inhibitor of:
Enzyme, PDE, and PDE7B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
YM 976, 10 mg | sc-204411 | 10 mg | $207.00 | |||
| US: Only available in the US | ||||||
YM 976, 50 mg | sc-204411A | 50 mg | $825.00 | |||
| US: Only available in the US | ||||||