Molecular structure of YM 022, CAS Number: 145084-28-2
YM 022 (CAS 145084-28-2)
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Application:
YM 022 is a highly potent and selective non-peptide CCK-BR silent antagonist
CAS Number:
145084-28-2
Purity:
≥98%
Molecular Weight:
516.60
Molecular Formula:
C32H28N4O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
YM 022 is a potent and selective inhibitor of the enzyme acyl-CoA:cholesterol acyltransferase (ACAT). It functions by blocking the esterification of cholesterol, which is a step in the biosynthesis of cholesterol esters. YM 022 can reduce the accumulation of cholesterol esters in various cell types, including macrophages and smooth muscle cells. YM 022 inhibits the synthesis of foam cells, which are implicated in the development of atherosclerosis.
YM 022 (CAS 145084-28-2) References
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- New molecular targets for treatment of peptic ulcer disease. | Lehmann, F., et al. 2003. Drugs. 63: 1785-97. PMID: 12921485
- AG-041R, a novel indoline-2-one derivative, stimulates chondrogenesis in a bipotent chondroprogenitor cell line CL-1. | Kitamura, H. and Okazaki, M. 2005. Osteoarthritis Cartilage. 13: 287-96. PMID: 15780642
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- Bidirectional modulation of GABAergic transmission by cholecystokinin in hippocampal dentate gyrus granule cells of juvenile rats. | Deng, PY. and Lei, S. 2006. J Physiol. 572: 425-42. PMID: 16455686
- Glycogen Synthase Kinase-3beta regulates Snail and beta-catenin during gastrin-induced migration of gastric cancer cells. | Mishra, P., et al. 2010. J Mol Signal. 5: 9. PMID: 20637111
- Motilin Stimulates Gastric Acid Secretion in Coordination with Ghrelin in Suncus murinus. | Goswami, C., et al. 2015. PLoS One. 10: e0131554. PMID: 26115342
- Permanent Photodynamic Activation of the Cholecystokinin 2 Receptor. | Tang, WZ. and Cui, ZJ. 2020. Biomolecules. 10: PMID: 32033232
- Spinal CCK contributes to somatic hyperalgesia induced by orofacial inflammation combined with stress in adult female rats. | Duan, LL., et al. 2021. Eur J Pharmacol. 913: 174619. PMID: 34748768
- Bromophenols from Symphyocladia latiuscula (Harvey) Yamada as Novel Cholecystokinin 2 Receptor Antagonists. | Paudel, P., et al. 2023. J Integr Neurosci. 22: 10. PMID: 36722239
- Are C-terminal octapeptide of cholecystokinin and [Leu11]gastrin-(5-17) different in stimulating acid secretion in isolated rabbit gastric glands? | Oiry, C., et al. 1995. Eur J Pharmacol. 294: 511-9. PMID: 8750713
- Characterization of a beta 3-adrenoceptor stimulating gastrin and somatostatin secretions in rat antrum. | Levasseur, S., et al. 1997. Am J Physiol. 272: G1000-6. PMID: 9176207
Inhibitor of:
CCK-BR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
YM 022, 5 mg | sc-204409 | 5 mg | $183.00 | |||
YM 022, 25 mg | sc-204409A | 25 mg | $769.00 |