Molecular structure of Y-25130 Hydrochloride, CAS Number: 123040-16-4
Y-25130 Hydrochloride (CAS 123040-16-4)
See product citations (3)
Alternate Names:
Azasetron hydrochloride
Application:
Y-25130 Hydrochloride is a potent and selective SR-3 antagonist
CAS Number:
123040-16-4
Purity:
99%
Molecular Weight:
386.28
Molecular Formula:
C17H20N3O3Cl•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Y-25130 is a potent and selective serotonin 5-HT3 antagonist. This product was demonstrated to be an antiemetic agent valuable for countering adverse effects seen in anticancer therapy including cisplatin. In studies involving rat hippocampal slices, Y-25130 exhibited dose-dependent neuroprotective effects against an ischemia-induced decrease in CA1 field potential. It has also been reported to attenuate the cocaine-induced decrease of intracranial self-stimulation (ICSS) reward thresholds in rats. Other results of the 5-HT3 antagonistic activity of Y-25130 led to the acceleration of gastric emptying in mice.
Y-25130 Hydrochloride (CAS 123040-16-4) References
- The 5-HT3 antagonist Y-25130 blocks cocaine-induced lowering of ICSS reward thresholds in the rat. | Kelley, SP. and Hodge, CW. 2003. Pharmacol Biochem Behav. 74: 297-302. PMID: 12479948
- Neuroprotective effect of 5-HT3 receptor antagonist on ischemia-induced decrease in CA1 field potential in rat hippocampal slices. | Kagami, Y., et al. 1992. Eur J Pharmacol. 224: 51-6. PMID: 1451743
- Blockade of 5-HT3 receptor-mediated currents in dissociated frog sensory neurones by benzoxazine derivative, Y-25130. | Yakushiji, T. and Akaike, N. 1992. Br J Pharmacol. 107: 853-7. PMID: 1472977
- The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist. | Fukuda, T., et al. 1991. Eur J Pharmacol. 196: 299-305. PMID: 1654255
- [Analysis of antiemetic effect of various dosage regimens of azasetron hydrochloride based on 5-HT3 receptor occupancy of serotonin]. | Yamada, Y., et al. 2007. Yakugaku Zasshi. 127: 353-7. PMID: 17268155
- Y25130 hydrochloride, a selective 5HT3 receptor antagonist has potent antimitogenic and apoptotic effect on HT29 colorectal cancer cell line. | Ataee, R., et al. 2010. Eur J Cancer Prev. 19: 138-43. PMID: 20010428
- Study of 5HT3 and HT4 receptor expression in HT29 cell line and human colon adenocarcinoma tissues. | Ataee, R., et al. 2010. Arch Iran Med. 13: 120-5. PMID: 20187666
- Determination of azasetron hydrochloride in rabbit plasma by liquid chromatography tandem mass spectrometry and its application. | Lin, G., et al. 2011. Biomed Chromatogr. 25: 1107-11. PMID: 21204117
- Stability of azasetron-dexamethasone mixture for chemotherapy-induced nausea and vomiting administration. | Fang, BX., et al. 2017. Oncotarget. 8: 106249-106257. PMID: 29290945
- Compatibility of dexamethasone sodium phosphate with 5-HT3 receptor antagonists in infusion solutions: a comprehensive study. | He, G., et al. 2017. Eur J Hosp Pharm. 24: 162-166. PMID: 31156929
- Effect of Y-25130, a selective 5-hydroxytryptamine3 receptor antagonist, on gastric emptying in mice. | Haga, K., et al. 1994. Arch Int Pharmacodyn Ther. 328: 344-55. PMID: 7625886
- High affinity binding of azasetron hydrochloride to 5-hydroxytryptamine3 receptors in the small intestine of rats. | Katayama, K., et al. 1997. Jpn J Pharmacol. 73: 357-60. PMID: 9165374
- Absorption characteristics of azasetron from rectal and oral routes in rabbits. | Moriyama, Y., et al. 1997. Biol Pharm Bull. 20: 701-3. PMID: 9212995
Inhibitor of:
GRP, and SR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Y-25130 Hydrochloride, 5 mg | sc-201150 | 5 mg | $96.00 |