XPC Antibody (A-5): sc-74411
- XPC Antibody (A-5) is a mouse monoclonal IgG1 κ, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 641-940 mapping at the C-terminus of XPC of human origin
- recommended for detection of XPC of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for XPC Antibody (A-5) for WB applications. This reagent is now offered in a bundle with XPC Antibody (A-5) (see ordering information below).
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XPC Antibody (A-5) is a mouse monoclonal IgG1 antibody that detects XPC in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). XPC plays a crucial role in the nucleotide excision repair (NER) pathway, which is essential for maintaining genomic stability by repairing bulky DNA lesions, such as those caused by ultraviolet light. Anti-XPC antibody (A-5) helps researchers study conditions like xeroderma pigmentosum, a condition characterized by extreme sensitivity to sunlight, where NER deficiencies increase skin cancer risk. XPC protein is primarily located in the nucleus, where XPC recognizes and binds to damaged DNA, facilitating the recruitment of other repair factors to initiate the repair process. Proper localization of XPC is vital for function, as any disruption can impair DNA repair mechanisms, leading to mutation accumulation and increased cancer susceptibility. XPC monoclonal antibody (A-5) serves as an invaluable tool for studying DNA repair mechanisms and the molecular basis of diseases associated with defective DNA repair pathways.
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XPC Antibody (A-5) References:
- Association of XPC gene polymorphisms with susceptibility to prostate cancer: evidence from 3,936 subjects. | Zou, YF., et al. 2013. Genet Test Mol Biomarkers. 17: 926-31. PMID: 24093803
- XPC promotes MDM2-mediated degradation of the p53 tumor suppressor. | Krzeszinski, JY., et al. 2014. Mol Biol Cell. 25: 213-21. PMID: 24258024
- XPC inhibits NSCLC cell proliferation and migration by enhancing E-Cadherin expression. | Cui, T., et al. 2015. Oncotarget. 6: 10060-72. PMID: 25871391
- Lack of associations between XPC polymorphisms and colorectal cancer: a meta-analysis. | Wang, G., et al. 2015. J BUON. 20: 770-4. PMID: 26214629
- XPC deficiency is related to APE1 and OGG1 expression and function. | de Melo, JT., et al. 2016. Mutat Res. 784-785: 25-33. PMID: 26811994
- Molecular basis for damage recognition and verification by XPC-RAD23B and TFIIH in nucleotide excision repair. | Mu, H., et al. 2018. DNA Repair (Amst). 71: 33-42. PMID: 30174301
- XPC Protein Improves Lung Adenocarcinoma Prognosis by Inhibiting Lung Cancer Cell Stemness. | Wang, W., et al. 2021. Front Pharmacol. 12: 707940. PMID: 34803670
- Regulation of XPC Binding Dynamics and Global Nucleotide Excision Repair by p63 and Vitamin D Receptor. | Wong, CT., et al. 2023. J Phys Chem B. 127: 2121-2127. PMID: 36877866
- Nucleotide excision repair in Human cell lines lacking both XPC and CSB proteins. | Lindsey-Boltz, LA., et al. 2023. Nucleic Acids Res. 51: 6238-6245. PMID: 37144462
- Natural small-molecules reverse Xeroderma Pigmentosum Complementation Group C (XPC) deficient-mediated drug-resistance in renal cell carcinoma. | Chen, R., et al. 2024. Phytomedicine. 124: 155310. PMID: 38215574
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
XPC Antibody (A-5) | sc-74411 | 200 µg/ml | $322.00 | |||
XPC Antibody (A-5): m-IgG Fc BP-HRP Bundle | sc-539512 | 200 µg Ab; 10 µg BP | $361.00 |