Xli 093 (CAS 646066-59-3)
Alternate Names:
Bis[8-ethynyl-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid] 1,3-propanediyl ester
Application:
Xli 093 is α5 subtype selective benzodiazepine/GABAA receptor antagonist
CAS Number:
646066-59-3
Molecular Weight:
602.60
Molecular Formula:
C33H26N6O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Xli 093 is an α5 subtype selective benzodiazepine/GABAA receptor antagonist. Xli 093 shows Ki = 5 nM at the α5 receptor in Ltk- cell membranes expressing human α5β3γ2 receptors; little or no affinity at other BDZ/ GABAA subtypes; does not trigger chloride currents in any subtype of tested subtypes, up to 1 μM in concentration; dose-dependently and completely inhibits diazepam stimulated currents in α5β3γ2 receptors.
Xli 093 (CAS 646066-59-3) References
Li, X., et al., Synthesis, in vitro affinity and efficacy of a Bis 8-ethynyl-4H-imidazo[1,5a]-[1,4]benzodiazepine analogue, the first bivalent a5 subtype selective BzR/ GABAA antagonist. J. Med. Chem. 46, 5567-5570, (2003)Inhibitor of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Xli 093, 5 mg | sc-264494 | 5 mg | $134.00 |