Molecular structure of XL-147 derivative 1, CAS Number: 1349796-36-6
XL-147 derivative 1 (CAS 1349796-36-6)
Alternate Names:
N-[4-({3-[(3,5-dimethoxyphenyl)amino]quinoxalin-2-yl}sulfamoyl)phenyl]-3-methoxy-4-methylbenzamide
Application:
XL-147 derivative 1 is a potent class I PI3K inhibitor
CAS Number:
1349796-36-6
Purity:
≥98%
Molecular Weight:
599.66
Molecular Formula:
C31H29N5O6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
XL-147 derivative 1 is active against class I PI3K (IC50 = 39, 113, 9 and 43 nM for p110α, β, γ and δ, respectively). XL765 also inhibits DNA-PK (IC50 = 150 nM) and mTOR (IC50 = 157 nM) but not XL-147 which shows IC50 values of > 15 μM. [1] XL765 treatment results in decreased cell viability in 13 PDA cell lines in a dose-dependent manner. XL-147 derivative 1, a dual-target PI3K/mTOR inhibitor, inhibits cell growth and apoptosis in many more cell lines and at lower concentrations as compared to the PI3K-selective inhibitors XL147 and PIK90.
Inhibitor of:
DNA-PK, mTOR, PI 3-kinase, PI 3-kinase p110 alpha, PI 3-kinase p110 beta, PI 3-kinase p110 delta, and PI 3-kinase p110 gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
XL-147 derivative 1, 5 mg | sc-364660 | 5 mg | $189.00 | |||
XL-147 derivative 1, 50 mg | sc-364660A | 50 mg | $1725.00 |