Molecular structure of Xestospongin D
Xestospongin D
Alternate Names:
XeD
Application:
Xestospongin D is a reversible blocker of IP3-mediated Ca2+ release
Molecular Weight:
462.71
Molecular Formula:
C28H50N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Xestospongin D, Xestospongia sp. is a reversible, membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 648 nM). Xestospongin D displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1).
Xestospongin D References
- A Xestospongin C-sensitive Ca(2+) store is required for cAMP-induced Ca(2+) influx and cAMP oscillations in Dictyostelium. | Schaloske, R., et al. 2000. J Biol Chem. 275: 8404-8. PMID: 10722673
- Two new alkaloids from Xestospongia sp., a New Caledonian sponge. | Quirion, JC., et al. 1992. J Nat Prod. 55: 1505-8. PMID: 1453184
- Membrane hyperpolarization is not required for sustained muscarinic agonist-induced increases in intracellular Ca2+ in arteriolar endothelial cells. | Cohen, KD. and Jackson, WF. 2005. Microcirculation. 12: 169-82. PMID: 15824039
- Regulation of skeletal muscle fiber type and slow myosin heavy chain 2 gene expression by inositol trisphosphate receptor 1. | Jordan, T., et al. 2005. J Cell Sci. 118: 2295-302. PMID: 15870113
- The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins. | Lauckner, JE., et al. 2005. Proc Natl Acad Sci U S A. 102: 19144-9. PMID: 16365309
- The effect of sevoflurane on intracellular calcium concentration from cholinergic cells. | Pinheiro, AC., et al. 2006. Brain Res Bull. 69: 147-52. PMID: 16533663
- Heterogeneous function of ryanodine receptors, but not IP3 receptors, in hamster cremaster muscle feed arteries and arterioles. | Westcott, EB. and Jackson, WF. 2011. Am J Physiol Heart Circ Physiol. 300: H1616-30. PMID: 21357503
- Antifilarial activity of marine sponge Haliclona oculata against experimental Brugia malayi infection. | Gupta, J., et al. 2012. Exp Parasitol. 130: 449-55. PMID: 22306280
- Function and expression of ryanodine receptors and inositol 1,4,5-trisphosphate receptors in smooth muscle cells of murine feed arteries and arterioles. | Westcott, EB., et al. 2012. J Physiol. 590: 1849-69. PMID: 22331418
- The mechanisms of energy crisis in human astrocytes after subarachnoid hemorrhage. | Kasseckert, SA., et al. 2013. Neurosurgery. 72: 468-74; discussion 474. PMID: 23151619
- Effects of parathyroid hormone-related peptide on the large conductance calcium-activated potassium channel and calcium homeostasis in vascular smooth muscle cells. | Burgazli, KM., et al. 2014. Postgrad Med. 126: 76-85. PMID: 24685970
- Apoptosis of alcohol-exposed human placental cytotrophoblast cells is downstream of intracellular calcium signaling. | Bolnick, JM., et al. 2014. Alcohol Clin Exp Res. 38: 1646-53. PMID: 24889927
- Measuring the length of the pore of the sheep cardiac sarcoplasmic reticulum calcium-release channel using related trimethylammonium ions as molecular calipers. | Tinker, A. and Williams, AJ. 1995. Biophys J. 68: 111-20. PMID: 7536054
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Xestospongin D, 50 µg | sc-222422 | 50 µg | $522.00 |