Molecular structure of Xanthurenic acid, CAS Number: 59-00-7
Xanthurenic acid (CAS 59-00-7)
Application:
Xanthurenic acid is a potent activator of group II mGluRs
CAS Number:
59-00-7
Purity:
≥95%
Molecular Weight:
205.17
Molecular Formula:
C10H7NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Xanthurenic acid selectively activates group II mGluRs in transfected HEK 293 cells at nanomolar concentrations. Xanthurenic acid is an activator of mGluR-2 and mGluR-3. Xanthurenic acid also attenuates cAMP formation in mouse cortical slices with mGluR-2 and mGluR-3 expression.
Xanthurenic acid (CAS 59-00-7) References
- Lens epithelial cell apoptosis and intracellular Ca2+ increase in the presence of xanthurenic acid. | Malina, H., et al. 2002. BMC Ophthalmol. 2: 1. PMID: 11934353
- Abnormal tryptophan metabolism and experimental diabetes by xanthurenic acid (XA). | Kotake, Y., et al. 1975. Acta Vitaminol Enzymol. 29: 236-9. PMID: 1244098
- Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: a study of their individual and synergistic actions. | López-Burillo, S., et al. 2003. J Pineal Res. 34: 269-77. PMID: 12662349
- Xanthurenic acid, an abnormal metabolite of tryptophan and the diabetic symptoms caused in albino rats by its production. | KOTAKE, Y. 1955. J Vitaminol (Kyoto). 1: 73-87. PMID: 13264335
- The Pseudomonas siderophore quinolobactin is synthesized from xanthurenic acid, an intermediate of the kynurenine pathway. | Matthijs, S., et al. 2004. Mol Microbiol. 52: 371-84. PMID: 15066027
- The antioxidant role of xanthurenic acid in the Aedes aegypti midgut during digestion of a blood meal. | Lima, VL., et al. 2012. PLoS One. 7: e38349. PMID: 22701629
- Modulation of hippocampal synaptic transmission by the kynurenine pathway member xanthurenic acid and other VGLUT inhibitors. | Neale, SA., et al. 2013. Neuropsychopharmacology. 38: 1060-7. PMID: 23303071
- Tetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid. | Haruki, H., et al. 2016. J Biol Chem. 291: 652-7. PMID: 26565027
- Kynurenine metabolism and xanthurenic acid formation in vitamin B6-deficient rat after tryptophan injection. | Takeuchi, F., et al. 1989. J Nutr Sci Vitaminol (Tokyo). 35: 111-22. PMID: 2732805
- Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors. | Fazio, F., et al. 2017. Neuropharmacology. 112: 365-372. PMID: 27342123
- Studies on the urinary excretion of xanthurenic acid in diabetics. | Hattori, M., et al. 1984. Acta Vitaminol Enzymol. 6: 221-8. PMID: 6524581
- Identification of xanthurenic acid as the putative inducer of malaria development in the mosquito. | Billker, O., et al. 1998. Nature. 392: 289-92. PMID: 9521324
- Xanthurenic acid induces gametogenesis in Plasmodium, the malaria parasite. | Garcia, GE., et al. 1998. J Biol Chem. 273: 12003-5. PMID: 9575140
Activator of:
mGluR-2, and mGluR-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Xanthurenic acid, 1 g | sc-258335 | 1 g | $71.00 |